METABOLIC ALTERATIONS IN THE NEONATE AND INFANT BRAIN DURING DEVELOPMENT - EVALUATION WITH PROTON MR SPECTROSCOPY
METABOLIC ALTERATIONS IN THE NEONATE AND INFANT BRAIN DURING DEVELOPMENT - EVALUATION WITH PROTON MR SPECTROSCOPY
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DOI：
10.1148/radiology.194.2.7529934
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发表时间：
1995-02-01
期刊：
影响因子：
19.7
通讯作者：
ISHII, Y
中科院分区：
文献类型：
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作者：
KIMURA, H;FUJII, Y;ISHII, Y
目得：为了评估氢-1磁共振（MR）波谱在评价发育中的brain.MATERIALS和METHODS：局部MR光谱的有用性，从78个新生儿和婴儿年龄1周到100个月的大脑回波时间为272毫秒。所有患者根据神经系统发育回顾性分为三组：（第2组，n = 21），正常，尽管有轻微的神经系统体征（组1，n = 23），正常（0组，n = 34）。结果：第2组中17例患者和第1组中8例患者显示N-乙酰天冬氨酸（NAA）/胆碱或NAA/肌酸比率与组0中获得的肌酸比率进行比较。磁共振波谱在区分第2组和第1组患者方面略有用（x（2）检验，P
PURPOSE: To evaluate the usefulness of hydrogen-1 magnetic resonance (MR) spectroscopy in the evaluation of the developing brain.MATERIALS AND METHODS: Localized MR spectra were obtained with an echo time of 272 msec from the brain of 78 neonates and infants aged 1 week to 100 months. All patients were retrospectively classified into three groups on the basis of neurologic development: abnormal (group 2, n = 21), normal despite minor neurologic signs (group 1, n = 23), and normal (group 0, n = 34).RESULTS: Seventeen patients in group 2 and eight patients in group 1 revealed abnormally low N-acetylaspartate (NAA)/choline or NAA/creatine ratios compared with those obtained in group 0. MR spectroscopy was slightly more useful in the differentiation of patients in groups 2 and 1 (x(2) test, P