Parasite-induced chronic inflammation is not exacerbated by immunotherapy before or during Trypanosoma cruzi Infection.
Parasite-induced chronic inflammation is not exacerbated by immunotherapy before or during Trypanosoma cruzi Infection.
复制标题
在克氏锥虫感染之前或期间，免疫治疗不会加剧寄生虫引起的慢性炎症。
DOI：
10.1128/cvi.00087-07
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Kahn,StuartJ
中科院分区：
文献类型：
--
作者：
Duthie,MalcolmS;Kahn,Maria;Zakayan,Arsen;White,Maria;Kahn,StuartJ
Trypanosoma cruziinfection causes Chagas' disease, a chronic inflammatory disease. The specific inflammatory responses that cause Chagas' disease remain unclear, but data argue that parasites that persist in the host stimulate chronic self-damaging immune responses. BecauseT. cruziappears to stimulate self-damaging responses, the enthusiasm to develop vaccines that boost antiparasite responses that might increase self-damaging responses has been limited. We previously demonstrated that immunization with aT. cruzi trans-sialidase protein or adoptive transfer oftrans-sialidase-specific T-cell clones decreased parasitemia, morbidity, and mortality. Here we report that immunization or adoptive transfer with the protein or clones, before or duringT. cruziinfection, boosts the anti-T. cruziimmune response without exacerbating acute or chronic tissue inflammation. These results argue that prophylactic and therapeutic immunotherapy for Chagas' disease can be developed safely.
