A chiral molecular recognition approach to the formation of optically active quaternary centres in aza-Henry reactions
A chiral molecular recognition approach to the formation of optically active quaternary centres in aza-Henry reactions
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DOI：
10.1039/b500618j
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发表时间：
2005-01-01
影响因子：
3.2
通讯作者：
Jorgensen, KA
中科院分区：
文献类型：
--
作者：
Knudsen, KR;Jorgensen, KA
提出了一种基于手性分子识别的不对称催化方法，通过手性Lewis酸和手性有机催化相结合在氮杂-亨利反应中形成光学活性四元中心，在催化剂负载量为5mol%的情况下，以良好的产率获得高达98%的ee和14：1的非对映异构体。
An approach to asymmetric catalysis based on chiral molecular recognition by the combination of chiral Lewis acids and chiral organocatalysis for the formation of optically active quarternary centers in the aza-Henry reaction is presented; this procedure leads to products with up to 98% ee and a diastereomeric ratio of 14 : 1 in excellent yields with catalyst loadings of 5 mol%.