Object recognition memory and the rodent hippocampus
Object recognition memory and the rodent hippocampus
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DOI：
10.1101/lm.1650110
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发表时间：
2010-01-01
影响因子：
2
通讯作者：
Clark, Robert E.
中科院分区：
文献类型：
--
作者：
Broadbent, Nicola J.;Gaskin, Stephane;Clark, Robert E.
在啮齿类动物中，新对象识别任务（NOR）已成为评估识别记忆的基准任务。然而，尽管它被广泛使用，但关于哪些大脑结构对任务表现重要还没有达成共识。我们评估了海马病变对NOR任务表现的顺行和逆行影响。大鼠对两个相同的物体进行12次5分钟的暴露，然后在最后一次暴露后的第1天、第4周或第8周接受双侧海马损伤或假手术。在术后2周的记忆保留测试中，海马病变组1-d和4周表现出物体识别记忆受损。相比之下，8周海马损伤组的表现与对照组相似，两组都表现出对新物体的偏好。然后对这些大鼠进行四次术后测试，使用独特的物体对，并在暴露阶段和测试阶段之间延迟3小时。海马病变产生中度和可靠的记忆损伤。结果表明，海马体在物体识别记忆中起重要作用。
In rodents, the novel object recognition task (NOR) has become a benchmark task for assessing recognition memory. Yet, despite its widespread use, a consensus has not developed about which brain structures are important for task performance. We assessed both the anterograde and retrograde effects of hippocampal lesions on performance in the NOR task. Rats received 12 5-min exposures to two identical objects and then received either bilateral lesions of the hippocampus or sham surgery 1 d, 4 wk, or 8 wk after the final exposure. On a retention test 2 wk after surgery, the 1-d and 4-wk hippocampal lesion groups exhibited impaired object recognition memory. In contrast, the 8-wk hippocampal lesion group performed similarly to controls, and both groups exhibited a preference for the novel object. These same rats were then given four postoperative tests using unique object pairs and a 3-h delay between the exposure phase and the test phase. Hippocampal lesions produced moderate and reliable memory impairment. The results suggest that the hippocampus is important for object recognition memory.