Ethnic differences in COMT genetic effects on striatal grey matter alterations associated with childhood ADHD: A voxel-based morphometry study in a Japanese sample
Ethnic differences in COMT genetic effects on striatal grey matter alterations associated with childhood ADHD: A voxel-based morphometry study in a Japanese sample
复制标题
DOI：
10.3109/15622975.2015.1102325
复制
发表时间：
2017-05
期刊：
影响因子：
--
通讯作者：
Koji Shimada;T. Fujisawa;Shinichiro Takiguchi;Hiroaki Naruse;H. Kosaka;H. Okazawa;A. Tomoda
中科院分区：
文献类型：
--
作者：
Koji Shimada;T. Fujisawa;Shinichiro Takiguchi;Hiroaki Naruse;H. Kosaka;H. Okazawa;A. Tomoda
摘要目标：注意力缺陷/多动障碍（ADHD）与介导高级认知功能的多巴胺能额-纹状体系统的缺陷有关。我们假设多巴胺调节基因，儿茶酚-O-甲基转移酶（COMT），对不同种族ADHD患者的神经系统有不同的影响。在患有ADHD的高加索儿童中，COMT Val纯合子先前已被证明与纹状体灰质体积（GMV）改变相关。通过使用基于体素的形态测量学，我们研究了亚洲ADHD儿童是否会表现出与白人样本相反的模式。研究方法：获得了患有ADHD的日本儿童（n = 17;平均年龄= 10.3岁）和典型发育（TD）儿童（n = 15;平均年龄= 12.8岁）的脑结构图像。还获得了ADHD组的COMT Val158Met基因型数据。结果：ADHD组与TD组相比，左侧纹状体GMV降低。这种降低的GMV是由COMT多态性调节的; Met携带者表现出比瓦尔/瓦尔基因型更小的纹状体GMV。结论：与之前在高加索人中的发现相比，COMT Met等位基因与日本ADHD儿童的纹状体GMV改变相关。这些结果表明，存在种族差异的COMT遗传效应ADHD相关的纹状体异常。
Abstract Objectives: Attention deficit/hyperactivity disorder (ADHD) is associated with deficits in the dopaminergic fronto-striatal systems mediating higher-level cognitive functions. We hypothesised that a dopamine-regulating gene, catechol-O-methyltransferase (COMT), would have differential effects on the neural systems of different ethnic samples with ADHD. In Caucasian children with ADHD, the COMT Val-homozygotes have been previously shown to be associated with striatal grey matter volume (GMV) alterations. By using voxel-based morphometry, we examined whether Asian children with ADHD would exhibit a pattern opposite to that found in Caucasian samples. Methods: Structural brain images were obtained for Japanese children with ADHD (n = 17; mean age = 10.3 years) and typically developing (TD) children (n = 15; mean age = 12.8 years). COMT Val158Met genotype data were also obtained for the ADHD group. Results: Reduced GMV in the left striatum was observed in the ADHD group versus the TD group. This reduced GMV was modulated by COMT polymorphism; Met-carriers exhibited smaller striatal GMV than the Val/Val genotype. Conclusions: Contrasting with previous findings in Caucasians, the COMT Met allele was associated with striatal GMV alterations in Japanese children with ADHD. These results suggest the existence of ethnic differences in the COMT genetic effect on ADHD-related striatal abnormalities.