Effect of surfactant on voltammetric behaviour of ornidazole
Effect of surfactant on voltammetric behaviour of ornidazole
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DOI：
10.1016/j.colsurfa.2008.11.054
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发表时间：
2009-04
期刊：
影响因子：
--
通讯作者：
R. Jain;R. Mishra;A. Dwivedi
中科院分区：
文献类型：
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作者：
R. Jain;R. Mishra;A. Dwivedi
本工作的目的是建立一种伏安法测定药物制剂中奥硝唑的含量，并讨论表面活性剂在电极反应催化中的有益应用。该方法快速、灵敏，可用于增溶体系中奥硝唑的定性和定量分析。在pH 2.5~12.0的磷酸盐缓冲液中，研究了奥硝唑在阴离子、阳离子、非离子表面活性剂介质中的伏安行为。在含有奥硝唑的电解液中加入非离子表面活性剂吐温20增强了还原电流信号，而阴离子表面活性剂十二烷基硫酸钠和阳离子表面活性剂十六烷基三甲基溴化铵对峰电流有轻微的增强作用。根据控制电位电解、库仑分析和光谱分析对还原机理进行了推测。还原过程是不可逆的，受扩散控制。建立了测定奥硝唑的分析方法，其线性范围为4.0×10−3~4.0×10−6molL−1，定量下限为1.2×10−6，检出限为3.6×10−7molL−1。奥硝唑在其药物配方中的分析表明，还原峰的平均回收率为98%。
The objective of the present work is to develop a voltammetric method for the determination of ornidazole in pharmaceutical formulations and it also deals with the beneficial use of surfactants in the catalysis of electrode reactions. The proposed method is rapid and sensitive for the qualitative and quantitative analysis of ornidazole in solubilized systems. The voltammetric behaviour of ornidazole has been studied in different surfactant media viz., anionic, cationic, non-ionic surfactants over the pH range 2.5 to 12.0 in phosphate buffer (0.2M). Addition of non-ionic surfactant (Tween 20) to the ornidazole containing electrolyte enhanced the reduction current signal while the anionic surfactant sodium lauryl sulphate and cationic surfactant cetyltrimethylammonium bromide showed a small enhancement in peak current. The mechanism of reduction has been postulated on the basis of controlled potential electrolysis, coulometry and spectral analysis. The reduction process is irreversible and was diffusion controlled. Analytical method with adequate precise and accuracy was developed for the determination of ornidazole with linear concentration range 4.0×10−3to 4.0×10−6molL−1. The lower limit of quantification (LOQ) and the lower limit of detection (LOD) were found to be 1.2×10−6and 3.6×10−7molL−1respectively. The analysis of ornidazole in its pharmaceutical formulation exhibited the mean recovery of 98% for the reduction peak.