CYTO-TOXIC AND MUTAGENIC EFFECTS OF STERIGMATOCYSTIN ON CULTURED CHINESE-HAMSTER CELLS
CYTO-TOXIC AND MUTAGENIC EFFECTS OF STERIGMATOCYSTIN ON CULTURED CHINESE-HAMSTER CELLS
复制标题
DOI：
10.1093/carcin/2.10.945
复制
发表时间：
1981-01-01
期刊：
影响因子：
4.7
通讯作者：
UENO, Y
中科院分区：
文献类型：
--
作者：
NODA, K;UMEDA, M;UENO, Y
在有或无代谢活化系统的情况下，研究了致癌真菌毒素杂色曲霉素（STC）对培养的中国仓鼠细胞的细胞毒性和致突变作用。STC直接作用于细胞可诱导细胞毒性和耐药突变，并呈时间和浓度依赖性。对STC疗效的分析表明，短期治疗比长期治疗效果好。在活化系统的存在下，STC的细胞毒性和致突变作用被强烈增强，1%的[大鼠肝]微粒体组分在诱导效应方面是最有效的。等毒性比较分析表明，直接处理和活化处理的致突变活性差别不大。
Cytotoxic and mutagenic effects of sterigmatocystin (STC), a carcinogenic mycotoxin, on cultured Chinese hamster cells were investigated in the presence or absence of a metabolic activation system. STC directly applied to the cells induced cytotoxicity and drug-resistant mutations in a time- and concentration-dependent manner. Analyses of the effects of STC showed that treatment for shorter periods was more effective than that for longer periods. In the presence of an activation system, cytotoxic and mutagenic effects of STC were strongly enhanced, and 1% of the [rat liver] microsome fraction was most efficient in inducing the effects. Analyses by equitoxic comparison showed that there was little difference in mutagenic activity between the direct treatment and the treatment using an activation system.