Skeletal muscle metabolic changes in peripheral arterial disease contribute to exercise intolerance: a point-counterpoint discussion
Skeletal muscle metabolic changes in peripheral arterial disease contribute to exercise intolerance: a point-counterpoint discussion
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DOI:
10.1191/1358863x04vm572ra
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发表时间:
2004-01-01
影响因子:
3.5
通讯作者:
Green, S
中科院分区:
文献类型:
--
作者:
Brass, EP;Hiatt, WR;Green, S
Patients with claudication have a marked impairment in exercise performance. Several factors contribute to this limitation, including reductions in large vessel blood flow and oxygen delivery as well as metabolic abnormalities in skeletal muscle. The relative contribution of these factors and their role in the pathophysiology of the exercise limitation is discussed using a point-counterpoint approach. Future directions for research conclude the discussion.