Organoids required! A new path to understanding human brain development and disease
Organoids required! A new path to understanding human brain development and disease
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DOI：
10.1038/nmeth.4557
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发表时间：
2018-01-01
期刊：
影响因子：
48
通讯作者：
Arlotta, Paola
中科院分区：
文献类型：
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作者：
Arlotta, Paola
最近，人类“大脑类器官”的开发极大地提高了我们研究人类大脑发育的能力，这种三维培养系统在体外还原性但复杂的组织中概括了人类大脑发育的选定方面。在这里，我讨论这个新模型系统带来的承诺和挑战。
Our ability to study the developing human brain has recently been dramatically advanced by the development of human 'brain organoids', three-dimensional culture systems that recapitulate selected aspects of human brain development in reductionist, yet complex, tissues in vitro. Here I discuss the promises and challenges this new model system presents.