Focal Fluid-Attenuated Inversion Recovery Hyperintensity Within Acute Diffusion-Weighted Imaging Lesions Is Associated With Symptomatic Intracerebral Hemorrhage After Thrombolysis
Focal Fluid-Attenuated Inversion Recovery Hyperintensity Within Acute Diffusion-Weighted Imaging Lesions Is Associated With Symptomatic Intracerebral Hemorrhage After Thrombolysis
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DOI：
10.1161/strokeaha.108.516740
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发表时间：
2008-12-01
期刊：
影响因子：
8.3
通讯作者：
Kang, Dong-Wha
中科院分区：
文献类型：
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作者：
Cho, A-Hyun;Kim, Jong S.;Kang, Dong-Wha
背景和目的：我们研究了急性梗死液体衰减反转恢复图像上的局灶性高信号是否与溶栓后的症状性脑出血（SICH）相关。在急性梗死中出现局灶性液体衰减反转恢复高信号并不能排除溶栓。SICH定义为出血性转化伴任何神经功能减退（SICH-1）或48小时内国立卫生研究院卒中量表评分增加≥ 4（SICH-2）。结果在纳入的88例患者中，27例（30.7%）患者观察到急性梗死病灶内的局灶性液体衰减反转恢复高信号。多变量分析显示，局灶性液体衰减反转恢复高信号与SICH-1独立相关（OR，13.64; 95% CI，1.51 - 123.28）和SICH-2（OR，10.44; 95%置信区间，结论-局灶性积液的存在-急性梗死内的衰减反转恢复高信号可能增加溶栓后症状性脑出血的风险。（中风。2008; 39：3424-3426）。
Background and Purpose-We investigated whether focal hyperintensity on fluid-attenuated inversion recovery image within acute infarcts is associated with symptomatic intracerebral hemorrhage (SICH) after thrombolysis.Methods-Patients with acute ischemic stroke who underwent MRI screening before thrombolysis were enrolled. The presence of focal fluid-attenuated inversion recovery hyperintensity within acute infarcts did not preclude thrombolysis. SICH was defined as hemorrhagic transformation with any neurological decline (SICH-1) or with an increase in National Institutes of Health Stroke Scale of >= 4 (SICH-2) within 48 hours.Results-Among 88 included patients, focal fluid-attenuated inversion recovery hyperintensity within acute infarct lesions was observed in 27 (30.7%) patients. Multivariate analysis showed that focal fluid-attenuated inversion recovery hyperintensity was independently associated with SICH-1 (OR, 13.64; 95% CI, 1.51 to 123.28) and SICH-2 (OR, 10.44; 95% CI, 1.11 to 98.35).Conclusion-The presence of focal fluid-attenuated inversion recovery hyperintensity within acute infarcts may increase the risk of symptomatic intracerebral hemorrhage after thrombolysis. (Stroke. 2008; 39: 3424-3426.)