Lumican expression in advanced colorectal cancer with nodal metastasis correlates with poor prognosis.
Lumican expression in advanced colorectal cancer with nodal metastasis correlates with poor prognosis.
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DOI：
10.3892/or.16.6.1225
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发表时间：
2006-12
期刊：
影响因子：
4.2
通讯作者：
T. Seya;N. Tanaka;S. Shinji;K. Yokoi;M. Koizumi;Nobuhisa Teranishi;K. Yamashita;T. Tajiri;T. Ishiwata;Z. Naito
中科院分区：
文献类型：
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作者：
T. Seya;N. Tanaka;S. Shinji;K. Yokoi;M. Koizumi;Nobuhisa Teranishi;K. Yamashita;T. Tajiri;T. Ishiwata;Z. Naito
Lumican是一个小的富含亮氨酸的蛋白多糖家族的成员，据报道，它在人类乳腺癌中过度表达。乳腺癌细胞外基质中lumican的表达与肿瘤分级高、雌激素受体水平低和年龄小有关。Lumican在结直肠癌中的表达此前已有报道，但Lumican在肿瘤中的作用尚不清楚。在这项研究中，我们研究了lumican在晚期结直肠癌中的表达和作用。对158例晚期结直肠癌伴淋巴结转移行根治性手术的患者进行免疫组化染色。在正常结直肠组织中，成纤维细胞和神经细胞中观察到lumican免疫反应性，但在结直肠上皮细胞中未观察到。Lumican定位于癌细胞的细胞质中，在158例结直肠癌患者中有99例（62.7%）检测到其过表达。临床病理上，肿瘤的表达与年龄、性别、组织学分型、静脉和淋巴浸润无关。然而，lumican表达倾向于与淋巴结转移的扩散和肿瘤浸润深度相关（p分别=0.136和0.135）。此外，高lumican表达患者的生存率明显低于低lumican表达患者（p=0.048）。这些结果表明，lumican表达是晚期结直肠癌伴淋巴结转移患者的潜在预后因素。
Lumican is a member of a small leucine-rich proteoglycan family, and it is reportedly overexpressed in human breast cancer. The expression of lumican in the extracellular matrix in breast cancer is associated with a high tumor grade, low estrogen receptor levels and young age. Lumican expression has been previously reported in colorectal cancer, but the role of lumican in the tumor is not well understood. In this study, we examined the expression and role of lumican in advanced colorectal cancer. Immunohistochemical staining was performed on 158 patients who underwent curative surgery for advanced colorectal cancer with lymph node metastasis. In the normal colorectal tissues, lumican immunoreactivity was observed in the fibroblasts and neural cells, but not in the colorectal epithelial cells. Lumican was localized in the cytoplasm of the cancer cells and its overexpression was detected in 99 of the 158 (62.7%) colorectal cancer patients. Clinicopathologically, there was no association of lumican expression with age, sex, histological typing, or venous and lymphatic invasion. However, lumican expression tended to correlate with the spread of lymph node metastasis and the depth of tumor invasion (p=0.136 and 0.135, respectively). Furthermore, the survival rate was significantly lower in patients with a high lumican expression level than in those with a low lumican expression level (p=0.048). These results indicate that lumican expression is a potential prognostic factor in patients with advanced colorectal cancer with nodal metastasis.