Origins and functions of the chlamydial inclusion
Origins and functions of the chlamydial inclusion
复制标题
DOI：
10.1016/s0966-842x(97)01061-5
复制
发表时间：
1997-07-01
影响因子：
15.9
通讯作者：
Heinzen, RA
中科院分区：
文献类型：
--
作者：
Hackstadt, T;Fischer, ER;Heinzen, RA
衣原体在内化后不久通过主动修饰空泡使其与含有鞘磷脂的胞吐囊泡融合而从内吞途径中解离。与这种分泌途径的相互作用似乎提供了一种致病机制，使衣原体在一个注定不会与溶酶体融合的位点建立自己。
Chlamydiae dissociate themselves from the endocytic pathway shortly after internalization by actively modifying the vacuole to become fusogenic with sphingomyelin-containing exocytic vesicles. Interaction with this secretory pathway appears to provide a pathogenic mechanism that allows chlamydiae to establish themselves in a site that is not destined to fuse with lysosomes.