Biomaterial-assisted biotherapy: A brief review of biomaterials used in drug delivery, vaccine development, gene therapy, and stem cell therapy.
Biomaterial-assisted biotherapy: A brief review of biomaterials used in drug delivery, vaccine development, gene therapy, and stem cell therapy.
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DOI：
10.1016/j.bioactmat.2022.01.011
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发表时间：
2022-11
影响因子：
18.9
通讯作者：
Wei Y
中科院分区：
文献类型：
--
作者：
Han X;Alu A;Liu H;Shi Y;Wei X;Cai L;Wei Y
临床前和临床研究表明，生物治疗因其广泛的治疗应用而成为近年来的热点研究课题，在各个领域都具有令人鼓舞的前景。然而，生物疗法的广泛应用受到了严峻挑战的限制，包括缺乏安全有效的输送系统和严重的副作用。由于生物材料独特的潜力，例如良好的生物相容性和生物活性，生物材料辅助生物治疗已被证明是一种有吸引力的策略。基于生物材料的递送系统具有足够的包装能力和多功能功能，能够实现药物在靶点的持续和局部释放。此外，生物材料可以为干细胞的增殖、分化、附着和迁移提供具有特定细胞外条件的利基，从而导致组织再生。本综述总结了生物材料在生物治疗中应用的最新研究，包括药物输送、疫苗开发、基因治疗和干细胞治疗。还讨论了生物材料辅助生物疗法的挑战和前景。概述生物材料在生物治疗中应用的最新临床前和临床研究，包括药物输送、疫苗开发、基因治疗和干细胞治疗。生物材料在提高生物治疗的疗效和安全性方面具有独特的优势。各种类型的生物材料可用于广泛的生物治疗。生物材料的功能可以通过改变其固有特性或周围环境来调节。
Biotherapy has recently become a hotspot research topic with encouraging prospects in various fields due to a wide range of treatments applications, as demonstrated in preclinical and clinical studies. However, the broad applications of biotherapy have been limited by critical challenges, including the lack of safe and efficient delivery systems and serious side effects. Due to the unique potentials of biomaterials, such as good biocompatibility and bioactive properties, biomaterial-assisted biotherapy has been demonstrated to be an attractive strategy. The biomaterial-based delivery systems possess sufficient packaging capacity and versatile functions, enabling a sustained and localized release of drugs at the target sites. Furthermore, the biomaterials can provide a niche with specific extracellular conditions for the proliferation, differentiation, attachment, and migration of stem cells, leading to tissue regeneration. In this review, the state-of-the-art studies on the applications of biomaterials in biotherapy, including drug delivery, vaccine development, gene therapy, and stem cell therapy, have been summarized. The challenges and an outlook of biomaterial-assisted biotherapies have also been discussed. An overview of the latest pre-clinical and clinical studies on the applications of biomaterials in biotherapy, including drug delivery, vaccine development, gene therapy, and stem cell therapy. Biomaterials possess unique advantages to improve the efficacy and safety of biotherapy. Various types of biomaterials can be used in a wide range of biotherapy. The functions of biomaterials can be tuned by changing their inherent properties or the surrounding environment.
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影响因子：
15.3
作者：
Bonifaz, L;Bonnyay, D;Mahnke, K;Rivera, M;Nussenzweig, MC;Steinman, RM
通讯作者：
Steinman, RM
影响因子：
14
作者：
Chan, Christina;Guo, Nining;Lin, Wenbin
通讯作者：
Lin, Wenbin
影响因子：
15
作者：
Alsaiari, Shahad K.;Patil, Sachin;Khashab, Niveen M.
通讯作者：
Khashab, Niveen M.
影响因子：
41.2
作者：
Caiazzo, Massimiliano;Okawa, Yuya;Lutolf, Matthias P.
通讯作者：
Lutolf, Matthias P.
DOI：
10.1016/s0140-6736(17)33326-3
发表时间：
2018-03-17
期刊：
Lancet (London, England)
影响因子：
--
作者：
Allemani C;Matsuda T;Di Carlo V;Harewood R;Matz M;Nikšić M;Bonaventure A;Valkov M;Johnson CJ;Estève J;Ogunbiyi OJ;Azevedo E Silva G;Chen WQ;Eser S;Engholm G;Stiller CA;Monnereau A;Woods RR;Visser O;Lim GH;Aitken J;Weir HK;Coleman MP;CONCORD Working Group
通讯作者：
CONCORD Working Group