Relative cerebral blood volume is a potential biomarker in late delayed radiation-induced brain injury
Relative cerebral blood volume is a potential biomarker in late delayed radiation-induced brain injury
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相对脑血容量是迟发性辐射诱发脑损伤的潜在生物标志物
DOI：
10.1002/jmri.25837
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发表时间：
2018-04-01
影响因子：
4.4
通讯作者：
Zhou, Dongxiao
中科院分区：
文献类型：
--
作者：
Xie, Ying;Huang, Haiwei;Zhou, Dongxiao
目的评估相对脑血容量（rCBV）是否能提供可靠的信息来评估迟发性放射性脑损伤的分期。材料与方法40例迟发性放射性脑损伤患者。使用配备8通道头部线圈的1.5T磁共振成像（MRI）系统对患者进行检查。在灌注加权成像（PWI）中使用回波平面成像（EPI）序列。通过点分辨光谱序列获得1H-MR光谱扫描的位置。根据rCBV值将颞叶病变分为两组：rCBV 1（rCBV升高[组2; n=14]）。比较两组的PWI和MRS参数以及形态学病变类型。形态学严重程度由两名影像学专家（J.L.和H.X.S.分别拥有16年和24年的经验）。如有必要，第三位影像学教授（Z.M.H.）有30年解决分歧的经验。评价形态学病变类型的标准是基于以前发表的标准。在测试数据的偏度后，使用Mann-Whitney U检验或Student's t检验，如appropriate.ResultsrCBV，相对脑血流量（rCBF），和相对平均通过时间（rMTT）在组2（n=14）显着高于组1（n=45）。（rCBV：1.21 ± 0.38 vs. 0.72 ± 0.32; P < 0.001; rCBF：1.13 ± 0.02 vs. 0.74 ± 0.04; P < 0.001; rMTT：1.10 ± 0.26 vs. 0.96 ± 0.20，P < 0.001）。组1的含胆碱化合物（CHO）/肌酸（Cr）和CHO/N-乙酰天冬氨酸（NAA）水平显著高于组2（CHO/Cr：1.89 +/- 1.83 vs. 1.22 +/- 1.31; P=0.016; CHO/NAA：1.85 +/- 3.50 vs. 1.17 +/- 0.75; P=0.022）。与rCBV升高相比，rCBV低的病变中存在更严重的形态学病变（总体严重程度：7.00 +/- 4.25 vs. 5.00 +/- 5.13; P=0.029）。证据等级：4技术有效性：第3阶段J. Magn. Reson。Imaging 2018;47：1112-1118.
PurposeTo assess whether relative cerebral blood volume (rCBV) can provide information to reliably evaluate the stages of late delayed radiation-induced brain injury.Materials and MethodsForty patients diagnosed with late delayed radiation-induced brain injury were enrolled. The patients were examined using a 1.5T magnetic resonance imaging (MRI) system equipped with an 8-channel head coil. An echo planar imaging (EPI) sequence was used in perfusion-weighted imaging (PWI). The location of 1H-MR spectroscopy scanning was acquired by a point-resolved spectroscopy sequence. Lesions of the temporal lobe were divided into one of two groups according to rCBV value: rCBV1 (elevated rCBV [group 2; n=14]). PWI and MRS parameters, as well as morphological lesion types, in these two groups were compared. Morphological severity was assessed independently and agreed on by two imaging specialists (J.L. and H.X.S., with 16 and 24 years' experience, respectively). If necessary, a third imaging professor (Z.M.H.) with 30 years' experience resolved disagreement(s). Standards for evaluating morphological lesion types were based on previously published criteria. After testing the skewness of data, the Mann-Whitney U-test or Student's t-test was used, as appropriate.ResultsrCBV, relative cerebral blood flow (rCBF), and relative mean transit time (rMTT) in group 2 (n=14) were significantly higher than in group 1 (n=45) (rCBV: 1.210.38 vs. 0.720.32, respectively; P < 0.001; rCBF: 1.130.02 vs. 0.740.04, respectively; P < 0.001; rMTT: 1.10 +/- 0.26 vs. 0.96 +/- 0.20, P < 0.001). The levels of choline-containing compounds (CHO) / creatine (Cr) and CHO/N-acetylaspartate (NAA) in group 1 were significantly greater than in group 2 (CHO/Cr: 1.89 +/- 1.83 vs. 1.22 +/- 1.31, respectively; P=0.016; CHO/NAA: 1.85 +/- 3.50 vs. 1.17 +/- 0.75, respectively; P=0.022). More severe morphological lesions were present in lesions with low rCBV compared with elevated rCBV (overall severity: 7.00 +/- 4.25 vs. 5.00 +/- 5.13, respectively; P=0.029).ConclusionElevated rCBV accompanied by a more conservative metabolic pattern and milder lesion(s) may represent a less advanced stage in the development of late delayed radiation-induced brain injury. Level of Evidence: 4 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;47:1112-1118.