Endoscopic video autofluorescence imaging may improve the detection of early neoplasia in patients with Barrett's esophagus
Endoscopic video autofluorescence imaging may improve the detection of early neoplasia in patients with Barrett's esophagus
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DOI：
10.1016/s0016-5107(04)02577-5
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发表时间：
2005-05-01
影响因子：
7.7
通讯作者：
Bergman, JJGHM
中科院分区：
文献类型：
--
作者：
Kara, MA;Peters, FP;Bergman, JJGHM
背景资料：本研究的目的是探讨检测高度异型增生（HGD）和早期癌症（EC）在Barrett食管（BE）与原型视频autofluorescence endoscopic.Methods的可行性：60例BE患者进行了评价与原型，高分辨率videoendoscopic，具有单独的电荷耦合器件的白色光内窥镜（WLE）和自体荧光成像（AFT）。非异型增生BE在AFT上显示为绿色，而潜在肿瘤区域显示为蓝色/紫色。首先使用WLE筛查BE是否有明显异常，然后通过AFT检查以检测其他病变。对疑似瘤形成的病变和AFT正常的对照区域进行取样，进行组织病理学评估。最后，随机4象限活检标本获得2厘米intervention.Results：诊断HGD/EC在22例患者中，1例患者没有明显的异常，和21有内镜下可检测到的领域与HGD/EC。在后21例患者中，6例仅用AFT检测到HGD/EC;另1例患者用AFT和随机活检检测到HGD/EC。在14例患者中，HGD/EC检测与WLE和AFT;在这14例患者中的3例，额外的病变含有HGD/EC检测AFT单独。结论：本研究的结果表明，视频AFT可能会提高检测HGD/EC在BE患者。
Background: The aim of this study was to investigate the feasibility of detecting high-grade dysplasia (HGD) and early cancer (EC) in Barrett's esophagus (BE) with a prototype video autofluorescence endoscope.Methods: Sixty patients with BE were evaluated with a prototype, high-resolution videoendoscope that has separate charge-coupled devices for white light endoscopy (WLE) and autofluorescence imaging (AFT). Nondysplastic BE appears green on AFT, whereas potentially neoplastic areas appear blue/violet. The BE was first screened with WLE for visible abnormalities and then was examined by AFT to detect additional lesions. Lesions that raised a suspicion of neoplasia and control areas that were normal on AFT were sampled for histopathologic assessment. Finally, random 4-quadrant biopsy specimens were obtained at 2-cm intervals.Results: A diagnosis of HGD/EC was made in 22 patients; one patient had no visible abnormality, and 21 had endoscopically detectable areas with HGD/EC. In 6 of the latter 21 patients, the HGD/EC was detected with AFT alone; in another patient, HGD/EC was detected with AFT and random biopsies. In 14 patients, HGD/EC was detected with both WLE and AFT; in 3 of these 14 patients, additional lesions containing HGD/EC were detected by AFT alone.Conclusions: The results of this study suggest that video AFT may improve the detection of HGD/EC in patients with BE.