Lung metastasectomy in adenoid cystic carcinoma (ACC) of salivary gland
Lung metastasectomy in adenoid cystic carcinoma (ACC) of salivary gland
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DOI：
10.1016/j.oraloncology.2005.04.014
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发表时间：
2005-10-01
期刊：
影响因子：
4.8
通讯作者：
Licitra, L
中科院分区：
文献类型：
--
作者：
Locati, LD;Guzzo, M;Licitra, L
为了明确外科治疗在ACC肺转移瘤中的作用，回顾性分析了20例ACC患者的肺转移瘤切除术。共行26例手术，首次手术切除时，11例（55%）患者切除边缘清晰（R 0），3例存活良好。9例残留疾病（R2）患者中有4例仍然存活。RO组和R2组的中位生存期分别为78个月和52个月（p = 0.4）; R 0组和R2组的中位无进展（FFP）分别为30个月和15个月（p = 0.2）。无病间隔≥ 36个月和≥ 6个转移灶的患者获得了更好的结局，并且双侧受累对于实现RO干预至关重要。肺切除术在高选择性ACC患者中提供了延长的FFP。然而，这是否可以转化为生存益处，仍有待证实。(c)2005爱思唯尔有限公司保留所有权利。
To define the role of surgical management of lung metastases in ACC. Twenty ACC patients referred to lung metastasectomy were retrospectively reviewed. Twenty-six operations were performed; at the first metastasectomy, a resection with clear margins (R0) was achieved in 11 patients (55%), 3 are alive and well. Four out of 9 patients with residual disease (R2) are still alive. Median survival after metastasectomy was 78 and 52 months for RO and R2 (p = 0.4); median freedom from progression (FFP) in R0 and R2 groups was 30 and 15 months (p = 0.2), respectively. A better outcome was obtained for patients with a disease-free interval >= 36 months and >= 6 metastases and bilateral involvement were critical in achieving a RO intervention. Lung metastasectomy provided a prolonged FFP in a high selected subset of patients with ACC. However, if this could be translated into a survival benefit, it is still to be demonstrated. (c) 2005 Elsevier Ltd. All rights reserved.