Application of Spin-Correlated Radical Pair System to Liposomal Drug-Delivery System under Exposure to Magnetic Fields
Application of Spin-Correlated Radical Pair System to Liposomal Drug-Delivery System under Exposure to Magnetic Fields
复制标题
自旋相关自由基对系统在磁场下脂质体药物递送系统中的应用
DOI：
10.1016/j.jmmm.2019.01.099
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发表时间：
2019
影响因子：
2.7
通讯作者：
Takashi Tadokoro
中科院分区：
文献类型：
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作者：
Hidenori Nakagawa;Mikio Ohuchi;Takashi Tadokoro
在本文中，我们使用抗癌氟他胺（FM）作为自由基配对药物来研究磁场是否可以通过生物膜物理性质的差异来控制脂质体药物释放。使用原始的空气冷却的UV-LED照射系统进行FM掺入的脂质体纳米颗粒（FM-LN）的照射。使用一对市售永磁体暴露于0.2 T的静磁场。为了评估药物释放潜力与自旋相关的自由基对机制的光化学反应中发展的生物膜，我们准备了各种类型的FM-LN配备可能的磁性控制。根据所制备的FM-LN的总体结果，认为药物释放不是仅由配对机制引起的。但是观察磁场对机制的影响的测试必须提供药物靶向的有用信息。我们强烈建议一种新的药物释放技术，使用这些脂质体纳米粒子配备有磁性控制。
In this paper, we used anti-cancer flutamide (FM) as a radical pair-forming drug to investigate whether magnetic fields can control a liposomal drug release through differences in the physical properties of biomembranes. Irradiations of FM-incorporated liposomal nanoparticles (FM-LNs) were performed using an original air-cooled UV-LED irradiation system. Exposure to a static magnetic field of 0.2 T was performed using a pair of commercially available permanent magnets. For evaluating the drug-release potentials with spin-correlated radical pair mechanisms on the photochemical reactions developing in biomembranes, we prepared various types of FM-LNs equipped with possible magnetic controls. According to the overall result of the prepared FM-LNs, the drug release is deemed not to be caused by only the pair mechanisms. But the tests observing the magnetic field effects on the mechanisms must provide useful information on drug targeting. We strongly propose a new drug-release technology using these liposomal nanoparticles equipped with magnetic controls.