COOPERATIVE FORMATION OF HIGH-ORDER OLIGOMERS BY RETINOID-X RECEPTORS - AN UNEXPECTED MODE OF DNA RECOGNITION
COOPERATIVE FORMATION OF HIGH-ORDER OLIGOMERS BY RETINOID-X RECEPTORS - AN UNEXPECTED MODE OF DNA RECOGNITION
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DOI：
10.1073/pnas.92.2.422
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发表时间：
1995-01-17
影响因子：
11.1
通讯作者：
PRIVALSKY, ML
中科院分区：
文献类型：
--
作者：
CHEN, HW;PRIVALSKY, ML
核激素受体是一种配体调控的转录因子，在后生动物体内平衡和分化中发挥作用。我们在这里报告，DNA识别的至少一类核受体，类视色素X受体（RXR），可以发生通过一个意想不到的机制，涉及蛋白质四聚体和其他高阶寡聚体的合作形成，这些寡聚体复合物的形成使RXR α和γ，但不是β，有效地调节转录通过响应元件识别RXR二聚体差。因此，寡聚体的形成在决定核受体识别DNA的特异性方面起着重要作用，并有助于基因调控中的同种型依赖性差异。
Nuclear hormone receptors are ligand-regulated transcription factors that function in metazoan homeostasis and differentiation. We report here that DNA recognition by at least one class of nuclear receptors, the retinoid X receptors (RXRs), can occur through an unanticipated mechanism involving the cooperative formation of protein tetramers and other high-order oligomers, Formation of these oligomeric complexes enables RXRs alpha and gamma, but not beta, to efficiently regulate transcription through response elements poorly recognized by RXR dimers. Thus, oligomer formation plays an important role in determining the specificity of DNA recognition by nuclear receptors and contributes to isoform dependent differences in gene regulation.