Etiology of chronic calcifying pancreatitis in Brazil: a report of 329 consecutive cases
Etiology of chronic calcifying pancreatitis in Brazil: a report of 329 consecutive cases
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DOI：
10.1007/bf02801872
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发表时间：
1986-12
期刊：
影响因子：
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通讯作者：
R. Dani;F. J. Penna;C. Nogueira
中科院分区：
文献类型：
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作者：
R. Dani;F. J. Penna;C. Nogueira
作者从1963年1月至1986年1月连续观察了329例慢性钙化性胰腺炎（CCP）。酒精中毒是282例（86%）的病因。34例（10%）未发现病因（特发性）。营养不良10例（3%），慢性家族性胰腺炎3例（0.9%）。酒精中毒患者平均发病年龄为36.5±10.5岁，特发性患者平均发病年龄为22.6±15.4岁，营养病因患者平均发病年龄为7.3±3.0岁。三组患者的平均年龄差异有统计学意义。224例酒精诱导的胰腺钙化（79%），32例特发性（94%），8例营养不良（80%）和1例家族性胰腺炎（33%）。所有病例的营养病因均表现为严重的蛋白质热量缺乏伴水肿，无患者主诉疼痛，但有9例胰腺功能不全。酒精成瘾患者平均每日酒精摄入量为396.6±286 g（范围80-1664 g），酒精中毒发病时间为19.1±6.8岁，酗酒时间为20.8±8.3（4-44）年。7例发生胰腺癌。酒精性CCP患者亲属中出现慢性胰腺炎6例。
The authors observed 329 consecutive cases of chronic calcifying pancreatitis (CCP) from January 1963 to January 1986. Alcoholism was the etiological agent in 282 cases (86%). In 34 patients (10%) no cause was detectable (idiopathic). Malnutrition was responsible for 10 cases (3%) and chronic familial pancreatitis was diagnosed in 3 cases (0.9%). The mean age at the apparent onset of symptoms was 36.5 ± 10.5 for the alcoholics, 22.6 ± 15.4 in the idiopathic cases and 7.3 ± 3.0 for the nutritional etiology patients. Mean age differences are statistically significant for the 3 groups. Pancreatic calcifications were found in 224 alcohol-induced cases (79%), in 32 idiopathic cases (94%), in 8 patients with malnutrition (80%) and in one patient with familial pancreatitis (33%). All cases of nutritional etiology presented severe protein-caloric deficiences with edema, and none complained of pain, but 9 had pancreatic insufficiency. Mean daily ethanol intake for the alcohol-addicted patients was 396.6 ± 286 g (range 80–1664 g) with the onset of alcoholism at 19.1 ± 6.8 yr old and 20.8 ± 8.3 (4–44) yr of alcohol indulgence. Pancreatic carcinoma developed in 7 cases. Six cases of chronic pancreatitis were seen among relatives in the group with CCP of alcoholic etiology.