Layer-by-Layer Hydrogen-Bonded Polymer Films: From Fundamentals to Applications
Layer-by-Layer Hydrogen-Bonded Polymer Films: From Fundamentals to Applications
复制标题
DOI：
10.1002/adma.200803653
复制
发表时间：
2009-08-14
影响因子：
29.4
通讯作者：
Sukhishvili, Svetlana A.
中科院分区：
文献类型：
--
作者：
Kharlampieva, Eugenia;Kozlovskaya, Veronika;Sukhishvili, Svetlana A.
近年来，人们对构建纳米层状材料越来越感兴趣，这些材料包括聚合物在固体衬底上的水基顺序组装。在反电荷聚合物的逐层组装研究领域，氢键驱动的自组装成为一种强有力的技术。氢键(HB)LBL材料为LBL薄膜提供了新的机会，这种薄膜比静电组装的LBL薄膜更难生产。具体地说，与HB组装相关的新特性包括：1)易于在温和的pH值下对环境pH值做出反应的薄膜；2)将HB薄膜转化为单组分或双组分超薄水凝胶材料的多种可能性；以及3)在超薄膜中包含具有低玻璃化转变温度的聚合物(例如聚环氧乙烷)。这些特性可以为HB LBL膜带来新的应用，如pH和/或温度响应型药物输送系统，具有可调机械性能的材料，在生理条件下可溶解的释放膜，以及燃料电池的质子交换膜。在这篇报告中，我们讨论了基于HB组装的LBL材料合成的最新进展，它们的结构-性质关系的研究，以及HB LBL结构在生物技术和生物医学中的应用前景。
Recent years have seen increasing interest in the construction of nanoscopically layered materials involving aqueous-based sequential assembly of polymers on solid substrates. In the booming research area of layer-by-layer (LbL) assembly of oppositely charged polymers, self-assembly driven by hydrogen bond formation emerges as a powerful technique. Hydrogen-bonded (HB) LbL materials open new opportunities for LbL films, which are more difficult to produce than their electrostatically assembled counterparts. Specifically, the new properties associated with HB assembly include: 1) the ease of producing films responsive to environmental pH at mild pH values, 2) numerous possibilities for converting HB films into single- or two-component ultrathin hydrogel materials, and 3) the inclusion of polymers with low glass transition temperatures (e.g., poly(ethylene oxide)) within ultrathin films. These properties can lead to new applications for HB LbL films, such as pH- and/or temperature-responsive drug delivery systems, materials with tunable mechanical properties, release films dissolvable under physiological conditions, and proton-exchange membranes for fuel cells. In this report, we discuss the recent developments in the synthesis of LbL materials based on HB assembly, the study of their structure-property relationships, and the prospective applications of HB LbL constructs in biotechnology and bio-medicine.