Advances in methods for atomic resolution macromolecular structure determination.
Advances in methods for atomic resolution macromolecular structure determination.
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DOI：
10.12688/f1000research.25097.1
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发表时间：
2020-01-01
期刊：
影响因子：
--
通讯作者：
Rodriguez, Jose A
中科院分区：
文献类型：
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作者：
Thompson, Michael C;Yeates, Todd O;Rodriguez, Jose A
最近的技术进步极大地增加了结构生物学的力量和范围。高分辨率低温电子显微镜、连续X射线晶体学和电子衍射的新发展尤其具有变革性。在这里，我们强调了一些最新的进展和当前的挑战，在原子分辨率的方法，阐明大分子及其复合物的结构和动力学性质的前沿。
Recent technical advances have dramatically increased the power and scope of structural biology. New developments in high-resolution cryo-electron microscopy, serial X-ray crystallography, and electron diffraction have been especially transformative. Here we highlight some of the latest advances and current challenges at the frontiers of atomic resolution methods for elucidating the structures and dynamical properties of macromolecules and their complexes.