INCREASED RESISTANCE TO STAPHYLOCOCCUS-AUREUS INFECTION AND ENHANCEMENT IN SERUM LYSOZYME ACTIVITY BY GLUCAN
INCREASED RESISTANCE TO STAPHYLOCOCCUS-AUREUS INFECTION AND ENHANCEMENT IN SERUM LYSOZYME ACTIVITY BY GLUCAN
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DOI：
10.1126/science.628841
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发表时间：
1978-01-01
期刊：
影响因子：
56.9
通讯作者：
DILUZIO, NR
中科院分区：
文献类型：
--
作者：
KOKOSHIS, PL;WILLIAMS, DL;DILUZIO, NR
葡聚糖是一种有效的RES刺激剂，其免疫生物学活性部分由巨噬细胞数量和功能的增加介导。在研究葡聚糖作为抗菌活性介体的作用时，尝试确定葡聚糖改变实验诱导的革兰氏阳性菌血症小鼠死亡率的能力，并增强大鼠的抗菌防御能力，如血清溶菌酶和吞噬活性所示。静脉注射葡聚糖后，血清溶菌酶浓度比对照浓度增加约7倍。血清溶菌酶的增加似乎与葡聚糖诱导的吞噬作用增加和诱导的巨噬细胞增生平行。先前用葡聚糖治疗的小鼠在用S.金黄色。葡聚糖显然赋予宿主抵抗细菌感染的增强状态。
Glucan is a potent RES stimulant whose immunobiological activity is mediated, in part, by an increase in the number and function of macrophages. In studying the role of glucan as a mediator of antibacterial activity, attempts were made to ascertain the ability of glucan to modify the mortality of mice with experimentally induced gram-positive bacteremia, and to enhance antibacterial defenses in rats as denoted by serum lysozyme and phagocytic activity. After i.v. administration of glucan, serum lysozyme concentrations were increased approximately 7-fold over control concentrations. The increase in serum lysozyme appeared to parallel the glucan-induced increase in phagocytosis and induced hyperplasia of macrophages. Prior treatment of mice with glucan significantly enhanced their survival when they were challenged systemically with S. aureus. Glucan apparently confers an enhanced state of host defense against bacterial infections.