Interferons and the Immunogenic Effects of Cancer Therapy.
Interferons and the Immunogenic Effects of Cancer Therapy.
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DOI：
10.1016/j.it.2015.09.007
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发表时间：
2015-11
影响因子：
16.8
通讯作者：
Minn AJ
中科院分区：
文献类型：
--
作者：
Minn AJ
我们对传统癌症疗法（如化疗和放疗）的耐药机制的理解主要集中在细胞固有特性上，这些特性可以拮抗DNA和其他细胞损伤的有害影响。然而，越来越清楚的是，免疫系统和/或先天免疫信号传导途径可以与这些内在机制整合，以深刻地影响治疗效果。在这种情况下，最近的证据表明，干扰素（IFN）信号转导在这种整合中具有重要作用，通过影响免疫和内在/非免疫决定因素的治疗反应。然而，IFN信号可以是免疫刺激和免疫抑制，在不同的疾病背景下决定这些结果的因素尚不清楚。在这里，我将讨论与这些二分功能相关的癌症调控和分子事件。
Much of our understanding on resistance mechanisms to conventional cancer therapies such as chemotherapy and radiation has focused on cell intrinsic properties that antagonize the detrimental effects of DNA and other cellular damage. However, it is becoming clear that the immune system and/or innate immune signaling pathways can integrate with these intrinsic mechanisms to profoundly influence treatment efficacy. In this context, recent evidence indicates that interferon (IFN) signaling has an important role in this integration by influencing immune and intrinsic/non-immune determinants of therapy response. However, IFN signaling can be both immunostimulatory and immunosuppressive, and the factors determining these outcomes in different disease settings are unclear. Here I discuss the regulation and molecular events in cancer that are associated with these dichotomous functions.