Increased risk of reported pertussis and hospitalization associated with pertussis in low birth weight children
Increased risk of reported pertussis and hospitalization associated with pertussis in low birth weight children
复制标题
DOI：
10.1016/s0022-3476(96)80131-4
复制
发表时间：
1996-05-01
影响因子：
5.1
通讯作者：
Davis, JP
中科院分区：
文献类型：
--
作者：
Langkamp, DL;Davis, JP
目的：确定低出生体重（LBW）儿童是否比正常出生体重（NBW）儿童在生命的前 2 年内患百日咳和百日咳并发症的风险更大。研究设计：我们对包含威斯康星州居民 1981 年 1 月 1 日至 1990 年 12 月 31 日期间出生儿童的全州信息的三个数据集进行了二次分析，我们确定了 2 岁以下儿童中所有报告的百日咳病例，以及将这些信息与出生证明数据和住院数据联系起来，以确定 LBW 与 NBW 儿童报告的百日咳相对风险，我们还比较了 LBW 和 NBW 儿童报告的百日咳并发症的频率。 结果：我们分析了 549 例百日咳病例的报告； 49 例发生在 LBW 儿童中，LBW 儿童比 NBW 儿童更容易报告百日咳（相对风险 1.86；95% 置信区间 1.33、2.38）。LBW 和 NBW 儿童的肺炎和癫痫发作率没有差异；然而，报告患有百日咳的 LBW 儿童比 NBW 儿童住院的可能性明显更高（相对风险 1.40；95% 置信区间 1.11、1.69）。结论：除了及时为所有婴儿接种疫苗外，还需要努力确定其他方法来降低 LBW 婴儿和儿童患百日咳的风险。
Objectives: To determine whether low birth weight (LBW) children are at greater risk of reported pertussis and complications of pertussis in the first 2 years of life than are normal birth weight (NBW) children.Study design: We performed a secondary analysis of three data sets containing statewide information among Wisconsin residents for children born between January 1, 1981, and December 31, 1990, We identified all reported cases of pertussis among children younger than 2 years of age and linked this information with birth certificate data and hospitalization data to determine the relative risk of reported pertussis in LBW compared with NBW children, We also compared the frequency of reported complications of pertussis in LBW and NBW children.Results: We analyzed reports of 549 pertussis cases; 49 cases occurred in LBW children, The LBW children were significantly more likely to have reported pertussis than were NBW children (relative risk 1.86; 95% confidence interval 1.33, 2.38), The rates of pneumonia and seizures did not differ among LBW and NBW children; however, LBW children with reported pertussis were significantly more likely to be hospitalized than were NBW children (relative risk 1.40; 95% confidence interval 1.11, 1.69).Conclusion: In addition to timely vaccination of all infants, efforts are needed to determine additional ways to reduce the risk of pertussis among LBW infants and children.