Diphenylarsinic acid poisoning from chemical weapons in Kamisu, Japan
Diphenylarsinic acid poisoning from chemical weapons in Kamisu, Japan
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DOI：
10.1002/ana.20290
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发表时间：
2004-11-01
影响因子：
11.2
通讯作者：
Shimojo, N
中科院分区：
文献类型：
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作者：
Ishii, K;Tamaoka, A;Shimojo, N
我们注意到一个新的临床综合征与突出的小脑症状的公寓楼居民在Kamisu，日本。提供饮用水的水井含有二苯胂酸，这是二苯氰胂或二苯氯胂的降解产物，二苯氰胂或二苯氯胂是为用作化学武器而开发的，会引起严重的呕吐和打喷嚏。二苯胂酸中毒的特征包括脑干-小脑和大脑症状。在一些婴儿中，磁共振图像显示与脑萎缩相关的智力低下是明显的。我们必须提高警惕，防止或尽量减少日本或其他地方进一步发生二苯胂酸中毒的影响。
We noted a new clinical syndrome with prominent cerebellar symptoms in apartment building residents in Kamisu, Japan. The well that provided drinking water contained diphenylarsinic acid, a degradation product of diphenylcyanoarsine or diphenylchloroarsine, which were developed for use as chemical weapons, inducing severe vomiting and sneezing. Characteristics of diphenylarsinic acid poisoning include brainstem-cerebellar and cerebral symptoms. Mental retardation associated with brain atrophy in magnetic resonance images was evident in some infants. We must be vigilant to prevent or minimize the effects of further diphenylarsinic acid poisoning in Japan or elsewhere.