Increased expression of the growth-associated protein-43 gene after primary motor cortex lesion in macaque monkeys.
Increased expression of the growth-associated protein-43 gene after primary motor cortex lesion in macaque monkeys.
复制标题
猕猴初级运动皮层损伤后生长相关蛋白 43 基因的表达增加。
DOI：
10.1016/j.neures.2015.04.007
复制
发表时间：
2015
影响因子：
2.9
通讯作者：
Isa T.
中科院分区：
文献类型：
--
作者：
Murata Y;Higo N;Oishi T;Isa T.
在脑损伤或中风后，强化运动训练如何恢复运动功能的问题仍然没有解决。在这里，我们表明，同病灶腹侧运动前皮质（PMV）和病灶周围的初级运动皮质（M1）的猕猴参与恢复手动灵巧后，病变的M1。通过鹅膏蕈氨酸注射，在M1的手指区域造成局灶性病变。这种病变最初引起对侧手的弛缓性麻痹，但随后在日常病变后运动训练过程中手部运动功能恢复，包括精确抓握。通过H215 O-正电子发射断层扫描对局部脑血流进行的脑成像显示，在恢复后早期，PMv的活动增强，在恢复后晚期，M1内的功能连接增加。通过蝇蕈醇在不同恢复期的药理学失活证实了这些区域在运动恢复中的因果作用。这些研究结果表明，在其余的主要运动和运动前皮质区，时间依赖性的可塑性变化的神经活动和连接参与功能恢复的运动缺陷所造成的M1病变。因此，很可能是PMv，一个远离病变核心的区域，在早期恢复期起着重要的作用，而病灶周围的M1有助于功能恢复，特别是在后期恢复期。
The question of how intensive motor training restores motor function after brain damage or stroke remains unresolved. Here we show that the ipsilesional ventral premotor cortex (PMv) and perilesional primary motor cortex (M1) of rhesus macaque monkeys are involved in the recovery of manual dexterity after a lesion of M1. A focal lesion of the hand digit area in M1 was made by means of ibotenic acid injection. This lesion initially caused flaccid paralysis in the contralateral hand but was followed by functional recovery of hand movements, including precision grip, during the course of daily postlesion motor training. Brain imaging of regional cerebral blood flow by means of H215O-positron emission tomography revealed enhanced activity of the PMv during the early postrecovery period and increased functional connectivity within M1 during the late postrecovery period. The causal role of these areas in motor recovery was confirmed by means of pharmacological inactivation by muscimol during the different recovery periods. These findings indicate that, in both the remaining primary motor and premotor cortical areas, time-dependent plastic changes in neural activity and connectivity are involved in functional recovery from the motor deficit caused by the M1 lesion. Therefore, it is likely that the PMv, an area distant from the core of the lesion, plays an important role during the early postrecovery period, whereas the perilesional M1 contributes to functional recovery especially during the late postrecovery period.