Human hair follicle regeneration following amputation and grafting into the nude mouse
Human hair follicle regeneration following amputation and grafting into the nude mouse
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DOI：
10.1111/1523-1747.ep12330565
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发表时间：
1996-12-01
影响因子：
6.5
通讯作者：
Horne, KA
中科院分区：
文献类型：
--
作者：
Jahoda, CAB;Oliver, RF;Horne, KA
在这项研究中，我们调查的能力，人类毛囊再生纤维形成球后，切断。我们从不同部位的终末毛囊中取出基底，并将毛囊移植到无胸腺小鼠身上，无论是仍然附着在皮肤移植物上还是作为单个毛囊的皮下植入物。在皮肤移植物上观察到外部毛发生长，并且毛囊的组织学显示真皮乳头和毛囊球结构的恢复。这一结果表明，毛囊在去除后再生其下部结构的能力，这是第一次在胡须毛囊上证明，可能是一种普遍现象。它强调了卵泡内特定细胞亚群的重要性以及真皮-表皮相互作用在成年卵泡活动中的作用。
In this study we investigated the capacity of the human hair follicle to regenerate a fiber-forming bulb after its amputation. We removed the bases from terminal follicles from a variety of sites and transplanted the follicles onto athymic mice, either still attached to a skin graft or as subcutaneous implants of individual follicles. External hair growth was observed on the skin grafts, and histology of the follicles revealed restoration of dermal papillae and follicle bulb structures. This result suggests that the capacity of hair follicles to regenerate their lower structures after removal, which was first demonstrated on whisker follicles, may be a general phenomenon. It emphasizes the importance of specific cellular subpopulations within the follicle and the role of dermal-epidermal interactions in adult follicle activities.