Cannabinoid Receptors and Their Relationship With Chronic Pain: A Narrative Review.
Cannabinoid Receptors and Their Relationship With Chronic Pain: A Narrative Review.
复制标题
DOI：
10.7759/cureus.10436
复制
发表时间：
2020-09-14
期刊：
影响因子：
--
通讯作者：
Khan S
中科院分区：
文献类型：
--
作者：
Anthony AT;Rahmat S;Sangle P;Sandhu O;Khan S
慢性疼痛的负担影响了许多人，导致痛苦和不适，以及传统治疗方法的许多副作用。大麻素受体天然存在于人体中，长期以来一直是抗伤害感受的兴趣。这些包括CB 1和CB 2受体，它们是治疗慢性炎性疼痛的有希望的候选者。受体的作用机制以及它们在炎症条件下如何控制疼痛表明，它可以成为控制这些症状的一种有效方法。许多研究表明，针对这些受体的靶向方法如何激活它们，促进细胞因子的释放，所有这些都导致抗炎作用和免疫系统调节。大麻素激活甘氨酸和γ-氨基丁酸（GABA）模型也显示出疼痛管理的疗效。慢性疾病，如骨关节炎，也显示出受益于这种相当大的治疗。然而，目前还不清楚大麻素系统如何与疼痛通路相关。因此，在这篇综述中，我们的目的是分析大麻素系统在慢性炎症性疼痛中的作用。
The burden of chronic pain has affected many individuals leading to distress and discomfort, alongside numerous side effects with conventional therapeutic approaches. Cannabinoid receptors are naturally found in the human body and have long been an interest in antinociception. These include CB1 and CB2 receptors, which are promising candidates for the treatment of chronic inflammatory pain. The mechanism of action of the receptors and how they approach pain control in inflammatory conditions show that it can be an adjunctive approach towards controlling these symptoms. Numerous studies have shown how the targeted approach towards these receptors has activated them promoting a release in cytokines, all leading to anti-inflammatory effects and immune system regulation. Cannabinoid activation of glycine and gamma-aminobutyric acid (GABA) models also showed efficacy in pain management. Chronic conditions such as osteoarthritis were shown to also benefit from this considerable treatment. However, it is unclear how the cannabinoid system works in relation with the pain pathway. Therefore, in this review we aim to analyse the role of the cannabinoid system in chronic inflammatory pain.
登录
查看更多内容
影响因子：
3.3
作者：
Nackley, AG;Makriyannis, A;Hohmann, AG
通讯作者：
Hohmann, AG
影响因子：
4.7
作者：
Kinsey, Steven G.;Mahadevan, Anu;Lichtman, Aron H.
通讯作者：
Lichtman, Aron H.
影响因子：
5.8
作者：
Alsalem, Mohammad;Haddad, Mansour;El-Salem, Khalid
通讯作者：
El-Salem, Khalid
DOI：
10.1016/bs.apha.2017.05.003
发表时间：
2017-01-01
期刊：
CANNABINOID PHARMACOLOGY
影响因子：
--
作者：
Starowicz, Katarzyna;Finn, David P.
通讯作者：
Finn, David P.
影响因子：
2.2
作者：
Milligan, Amber L.;Szabo-Pardi, Thomas A.;Burton, Michael D.
通讯作者：
Burton, Michael D.