Electrophysiological study on sensory nerve activity from the submandibular salivary gland in rats
Electrophysiological study on sensory nerve activity from the submandibular salivary gland in rats
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DOI：
10.1016/j.brainres.2017.12.015
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发表时间：
2018-02-01
期刊：
影响因子：
2.9
通讯作者：
Fujita, Masako
中科院分区：
文献类型：
--
作者：
Matsuo, Ryuji;Kobashi, Motoi;Fujita, Masako
为了评估来自唾液腺的传入信息的作用，我们分析了支配麻醉大鼠下颌下腺的感觉神经的神经活动。通过副交感神经供应的感觉神经对施加在主导管和腺体表面的机械压力做出反应，而交感神经供应中的感觉神经仅对腺体做出反应。交感神经和副交感神经通路中的感觉神经对通过将盐水逆行注射到主管道中产生的管道系统中的压力作出反应。产生传入放电的阈值压力高于电刺激副交感分泌神经诱发的最大分泌压力。逆行导管注射药物相关的炎症过程（辣椒素和缓激肽）引起强烈的多单位放电的感觉神经的两条路线。交感神经通路的感觉神经对动脉结扎腺体有反应。这些结果表明，交感神经和副交感神经途径的感觉神经主要传导有害信息，交感神经途径的感觉神经对缺血有反应，并可能控制腺体的血流。(C)2017爱思唯尔B.V.保留所有权利。
To evaluate the role of afferent information from the salivary gland, we analyzed the neural activity of the sensory nerve innervating the submandibular gland in anesthetized rats. The sensory nerves running through the parasympathetic nerve supply responded to mechanical pressure applied to the surface of the main duct and the body of the gland, whilst those in the sympathetic nerve supply responded only to the body of the gland. The sensory nerves in the sympathetic and parasympathetic nerve routes responded to pressure in the duct system produced by a retrograde injection of saline into the main duct. The threshold pressure for production of afferent discharges was higher than the maximum secretory pressure evoked by electrical stimulation of the parasympathetic secretory nerve. The retrograde ductal injection of drugs related to the inflammatory process (capsaicin and bradykinin) evoked intense multi-unit discharges in the sensory nerves of both routes. The sensory nerve in the sympathetic route was responsive to ligation of the artery to the gland. These results suggest that sensory nerves in the sympathetic and parasympathetic routes mainly conduct noxious information, and that those in the sympathetic route are responsive to ischemia and may control blood flow of the gland. (C) 2017 Elsevier B.V. All rights reserved.