Blueberry Leaf Polyphenols Prevent Body Fat Accumulation in Mice Fed High-fat, High-sucrose Diet
Blueberry Leaf Polyphenols Prevent Body Fat Accumulation in Mice Fed High-fat, High-sucrose Diet
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DOI：
10.5650/jos.ess18226
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发表时间：
2019-05-01
影响因子：
1.5
通讯作者：
Yamasaki, Masao
中科院分区：
文献类型：
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作者：
Fujii, Kento;Ota, Yuma;Yamasaki, Masao
蓝莓叶目前是一种流行的膳食补充剂。研究了饲粮中添加蓝莓叶及其活性成分对人体脂肪积累的影响。C57BL/6J小鼠分别饲喂高脂高糖饲粮，添加或不添加3%蓝莓叶提取物（BLEx）或3%浓缩多酚BLEx (CP BLEx)，为期8周。与喂食不含蓝莓叶的高脂、高糖饮食的小鼠相比，BLEx和CP BLEx显著降低了体重和脂肪组织增重。脂肪细胞变小，肝脏脂质积累明显受到抑制。这些影响在喂食CP BLEx的小鼠中比喂食BLEx的小鼠更为明显。综上所述，研究结果表明，蓝莓叶可以抑制高脂肪、高蔗糖饮食小鼠体内脂肪的积累，这种抑制作用可归因于蓝莓叶提取物中的多酚成分。
Blueberry leaf is currently a popular dietary supplement. Effects of dietary blueberry leaf and its active components on body fat accumulation were examined. C57BL/6J mice were fed high-fat, high-sucrose diet with or without 3% blueberry leaf extract (BLEx) or 3% concentrated-polyphenolic BLEx (CP BLEx) for 8 weeks. Compared to mice fed a high-fat, high-sucrose diet without blueberry leaf, BLEx and CP BLEx significantly reduced body weight and adipose tissue weight gain. Adipocytes were also smaller and and liver lipid accumulatioin was significantly inhibited in mice fed either BLEx or CP BLEx. These effects tended to be more pronounced in mice fed CP BLEx compared to in mice fed BLEx. Together, results suggest that blueberry leaf inhibits body fat accumulation typically observed in mice fed a high-fat, high-sucrose diet, and that inhibition is attributable to polyphenolic components in leaf extracts.