A methylprednisolone-loaded and core-shell nanofiber-covered stent-graft to prevent inflammation and reduce degradation in aortic dissection.
A methylprednisolone-loaded and core-shell nanofiber-covered stent-graft to prevent inflammation and reduce degradation in aortic dissection.
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一种负载甲基泼尼松龙、核壳纳米纤维覆盖的覆膜支架，可预防主动脉夹层炎症并减少降解
DOI：
10.1186/s40824-022-00259-5
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发表时间：
2022-04-25
影响因子：
11.3
通讯作者：
Jing Z
中科院分区：
文献类型：
--
作者：
Liu J;Zhu H;Pei Y;Zhang H;Zhou J;Jing Z
覆膜支架诱导的炎症是主动脉夹层中主动脉瓣不良重塑的独立风险因素。在这种情况下，我们询问了甲基强的松龙负载的覆膜支架是否可以减少炎症和降解。首先，采用同轴静电纺丝技术制备了甲基强的松龙包裹在聚（L-丙交酯-己内酯）纳米纤维内部的核壳膜，用于药物的可控释放。其次，进行了体外研究，以评价骨水泥补片的生物相容性。第三，建立猪主动脉夹层模型来研究载甲泼尼龙覆膜支架的治疗效果。结果表明，具有甲泼尼龙-聚己内酯核层和聚（L-丙交酯-共己内酯）壳层的纳米纤维涂层膜可以有效地维持药物的体外释放。体内研究表明，载甲泼尼龙的覆膜支架可以通过调节炎症反应来减少主动脉夹层的降解。总体而言，通过同轴血管扩张的可控药物释放是减轻主动脉炎症和促进覆膜支架植入后主动脉重构的有希望的方法。在线版本包含补充材料，可通过10.1186/s40824-022-00259-5获得。
Stent-graft-induced inflammation is an independent risk factor for adverse aortic remodeling in aortic dissection. In this context, we asked that whether a methylprednisolone-loaded stent-graft could reduce inflammation and degradation. First, a coaxial electrospinning technique was used to create a core-shell film with methylprednisolone encapsulated in the inner of poly (L-lactide-co-caprolactone) nanofibers for controllable drug release. Second, an in vitro study was conducted to evaluate the biocompatibility of the nanofiber meshes. Third, the porcine aortic dissection model was developed to investigate the therapeutic effects of the methylprednisolone-loaded stent-graft. The results demonstrated that the nanofiber-coated film with a methylprednisolone-poly-caprolactone core layer and a poly (L-lactide-co-caprolactone) shell layer could effectively sustain drug release in vitro. In vivo study showed that the methylprednisolone-loaded stent-graft could reduce degradtion of aortic dissection by regulating inflammation. Overall, the controllable drug release by coaxial nanofiber is a promising approach to alleviate aortic inflammation and promote aortic remodeling after stent-graft implantation. The online version contains supplementary material available at 10.1186/s40824-022-00259-5.
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