Beneficial effect of tacrolimus on myasthenia gravis with thymoma
Beneficial effect of tacrolimus on myasthenia gravis with thymoma
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DOI：
10.1097/01.nrl.0000256352.77668.ef
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发表时间：
2007-03-01
期刊：
影响因子：
1.2
通讯作者：
Matsumoto, Toshio
中科院分区：
文献类型：
--
作者：
Mitsui, Takao;Kunishige, Makoto;Matsumoto, Toshio
我们研究了他克莫司对重症肌无力（MG）的作用。5例胸腺瘤患者和5例无胸腺瘤患者接受了胸腺切除术，但表现出持续的肌无力症状。口服他克莫司可显著改善所有患者治疗后1、3和6个月的MG评分（P < 0.05），胸腺瘤组的改善程度显著高于非胸腺瘤组（P < 0.05）。然而，两组的抗乙酰胆碱受体滴度均无显著变化。这表明胸腺瘤MG胸腺切除术后免疫抑制治疗的一个特殊应用。
We examined the effect of tacrolimus on myasthenia gravis (MG). Five patients with thymoma and 5 patients without thymoma underwent prior thymectomy but showed persistent myasthenic symptoms. Oral administration with tacrolimus significantly improved MG scores 1, 3, and 6 months following the beginning of treatment in all patients (P < 0.05), and the improvement was significantly higher in the thymoma group compared with the nonthymoma group (P < 0.05). However, there was no significant change in antiacetylcholine receptor titers in either group. This indicates a particular application of immunosuppressive therapy for thymomatous MG following thymectomy.