Reduction in subthalamic 8-35 Hz oscillatory activity correlates with clinical improvement in Parkinson's disease
Reduction in subthalamic 8-35 Hz oscillatory activity correlates with clinical improvement in Parkinson's disease
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DOI：
10.1111/j.1460-9568.2006.04717.x
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发表时间：
2006-04-01
影响因子：
3.4
通讯作者：
Brown, P
中科院分区：
文献类型：
--
作者：
Kühn, AA;Kupsch, A;Brown, P
帕金森氏病（PD）患者的丘脑下核（STN）在8-35 Hz波段出现强烈的神经元活动同步，并表现为振荡局部场电位（LFP）活动。为了测试这种同步是否可能导致运动迟缓和僵硬，我们寻求STN在8-35 Hz时抑制同步与左旋多巴减少帕金森病之间的相关性。用STN脑深部刺激电极记录9例PD患者服药和停药时的lfp。LFP功率计算在8-35 Hz频带内17面（未服药）最突出的频谱峰的频率上，以及在60-90 Hz频带内任何峰值的频率上，如果存在（7面，服药）。根据统一帕金森病评定量表（UPDRS）的评估，左旋多巴诱导的LFP功率在这两个频率范围内的降低与运动损伤的改善相关。左旋多巴减少8-35 Hz频段的峰值活动与左旋多巴改善对侧半身运动UPDRS评分（r = 0.811, P < 0.001）和半身运动-强直亚评分（r = 0.835, P < 0.001）呈正相关，但与震颤无关。峰值60-90 Hz LFP功率与UPDRS整体评分之间存在负相关趋势，表明正相关是相对特定于频率的。我们的研究结果支持左旋多巴诱导的PD患者运动迟缓和僵硬的改善与STN区域频率< 35 Hz时群体同步性的降低之间的联系。
Strong synchronization of neuronal activity occurs in the 8-35 Hz band in the subthalamic nucleus (STN) of patients with Parkinson's disease (PD) and is evident as oscillatory local field potential (LFP) activity. To test whether such synchronization may contribute to bradykinesia and rigidity, we sought correlations between the suppression of synchronization at 8-35 Hz in STN and the reduction in Parkinsonism with levodopa. LFPs were recorded on and off medication from STN deep-brain stimulation electrodes in nine PD patients. LFP power was calculated over the frequencies of the most prominent spectral peak within the 8-35 Hz frequency band on each of 17 sides (off medication), and over the frequencies of any peak in the 60-90 Hz band, if present (seven sides, on medication). Levodopa-induced reduction of LFP power over these two frequency ranges was then correlated with improvement in motor impairment as assessed by the Unified Parkinson's Disease Rating Scale (UPDRS). The reduction in peak activity in the 8-35 Hz band with levodopa positively correlated with the improvement in the contralateral hemibody motor UPDRS score with levodopa (r = 0.811, P < 0.001) as well as with hemibody subscores of akinesia-rigidity (r = 0.835, P < 0.001), but not tremor. A trend for negative correlations was found between peak 60-90 Hz LFP power and UPDRS hemibody score, suggesting that positive correlations were relatively frequency-specific. Our results support a link between levodopa-induced improvements in bradykinesia and rigidity and reductions in population synchrony at frequencies < 35 Hz in the region of the STN in patients with PD.