SPIKE-WAVE DISCHARGES AND SLEEP-WAKE STATES IN RATS WITH ABSENCE EPILEPSY
SPIKE-WAVE DISCHARGES AND SLEEP-WAKE STATES IN RATS WITH ABSENCE EPILEPSY
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DOI：
10.1016/0920-1211(91)90055-k
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发表时间：
1991-09-01
影响因子：
2.2
通讯作者：
VANLUIJTELAAR, ELJM
中科院分区：
文献类型：
--
作者：
DRINKENBURG, WHIM;COENEN, AML;VANLUIJTELAAR, ELJM
研究了大鼠棘波放电的发生与觉醒水平的日常波动之间的关系。8只WAG/Rij品系大鼠作为实验对象，该品系是失神型特发性全身性癫痫的动物模型，它们配备了皮质脑电图和颈部肌电图电极。研究发现，棘波放电主要发生在轻度慢波睡眠和被动觉醒期间。快速眼动睡眠、主动觉醒和深度慢波睡眠较不易发生棘波放电。最后，棘波放电往往在过渡状态中占优势。研究表明，觉醒水平的稳定程度在失神发作的起源中起着关键作用。
The occurrence of spike-wave discharges was studied in relation to the daily fluctuations of vigilance level in rats. Eight rats of the WAG/Rij strain, an animal model for idiopathic generalized epilepsy of the absence type, which were equipped with cortical EEG and nuchal EMG electrodes, served as subjects. It was found that spike-wave discharges predominantly occur during light slow wave sleep and passive wakefulness. REM sleep, active wakefulness, and deep slow wave sleep are less susceptible to the occurrence of spike-wave discharges. Finally, spike-wave discharges tend to prevail in transitional states. A crucial role for the degree of stability of the level of vigilance in the genesis of absence seizures is suggested.