The role of metabolomics in determination of new dietary biomarkers.
The role of metabolomics in determination of new dietary biomarkers.
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DOI：
10.1017/s0029665116002974
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发表时间：
2017-08-01
期刊：
影响因子：
--
通讯作者：
Brennan, L
中科院分区：
文献类型：
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作者：
O'Gorman, A;Brennan, L
传统的饮食摄入量评估方法容易出错;为了改进和增强这些方法，人们对饮食生物标志物的鉴定越来越感兴趣。代谢组学已经成为膳食生物标志物发现领域的关键工具，迄今为止，代谢组学的使用已经确定了许多推定的生物标志物。鉴定新的摄入生物标志物的应用通常采用三种方法：（1）特定的急性干预研究，以鉴定特定的摄入生物标志物;（2）通过与自我报告的特定食物/食物组的摄入相关联，在队列研究中搜索生物标志物;（3）结合代谢组学谱分析饮食模式，以鉴定生物标志物和营养类型。代谢组学中采用了许多分析技术，因为目前还没有能够测量整个代谢组的单一技术。这些方法各有其优点和缺点。本文综述了代谢组学在新的膳食生物标志物检测中的应用。此外，报告还将讨论外地目前的一些挑战和未来展望。
Traditional methods for the assessment of dietary intake are prone to error; in order to improve and enhance these methods increasing interest in the identification of dietary biomarkers has materialised. Metabolomics has emerged as a key tool in the area of dietary biomarker discovery and to date the use of metabolomics has identified a number of putative biomarkers. Applications to identify novel biomarkers of intake have in general taken three approaches: (1) specific acute intervention studies to identify specific biomarkers of intake; (2) searching for biomarkers in cohort studies by correlating to self-reported intake of a specific food/food group(s); (3) analysing dietary patterns in conjunction with metabolomic profiles to identify biomarkers and nutritypes. A number of analytical technologies are employed in metabolomics as currently there is no single technique capable of measuring the entire metabolome. These approaches each have their own advantages and disadvantages. The present review will provide an overview of current technologies and applications of metabolomics in the determination of new dietary biomarkers. In addition, it will address some of the current challenges in the field and future outlooks.