Structural changes of the intradural arteries following subarachnoid hemorrhage.
Structural changes of the intradural arteries following subarachnoid hemorrhage.
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DOI：
10.3171/jns.1972.37.6.0715
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发表时间：
1972-12
影响因子：
4.1
通讯作者：
L. Conway;L. W. Mcdonald
中科院分区：
文献类型：
--
作者：
L. Conway;L. W. Mcdonald
对12例自发性蛛网膜下腔出血后1天至15个月死亡的连续尸检病例进行了硬膜内动脉的组织学研究。在所有存活4周或以上的患者和1例存活4天的患者中，颅内动脉的管腔被内皮下肉芽组织所狭窄，这些肉芽组织使内膜增厚。在所有7例颅内动脉结构改变的病例中，出血部位附近的血管受累; 4例远离出血部位的血管也受累。变化通常局限于具有突出肌肉层的大动脉，并局限于蛛网膜下腔。内膜增厚的存在和程度与蛛网膜下腔血液或其分解产物的分布和量相关。这一过程显然不代表闭塞性动脉内膜炎，它只涉及向梗塞脑供血的血管，而可能是对机械性或缺氧性损伤的反应。
✓ The histology of the intradural arteries was studied in 12 consecutive autopsy cases of patients dying 1 day to 15 months after their initial spontaneous subarachnoid hemorrhage. In all patients surviving 4 weeks or more and in one surviving 4 days, the lumina of the intracranial arteries were narrowed by subendothelial granulation tissue which thickened the intima. In all seven cases with structural changes in the intracranial arteries, vessels near the site of hemorrhage were involved; in four cases vessels remote from the site of hemorrhage were also involved. Changes were usually restricted to large arteries with a prominent muscular layer and confined to the subarachnoid space. The presence and degree of intimal thickening correlated with the distribution and amount of subarachnoid blood or its breakdown products. This process apparently does not represent an obliterative endarteritis involving vessels exclusively supplying infarcted brain, but is probably a reaction to mechanical or anoxic damage ...