Voltage-gated calcium channel subunits from platyhelminths: Potential role in praziquantel action
Voltage-gated calcium channel subunits from platyhelminths: Potential role in praziquantel action
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DOI：
10.1016/j.ijpara.2006.02.002
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发表时间：
2006-05-31
影响因子：
4
通讯作者：
Greenberg, Robert M.
中科院分区：
文献类型：
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作者：
Jeziorski, Michael C.;Greenberg, Robert M.
电压门控钙 (Ca2+) 通道提供了 Ca2+ 流入的途径，这是肌肉、神经和其他可兴奋细胞中 Ca2+ 依赖性反应的基础。它们也是多种药物和毒素的目标。 Ca2+ 通道是多亚基蛋白质复合物，由成孔 α、亚基和其他调节亚基（包括 β 亚基）组成。在这里，我们回顾了血吸虫 Ca2+ 通道亚基的结构和功能，特别强调在这些寄生虫中发现的变异 Ca2+ 通道 β 亚基 (Ca-nu beta var)。特别是，我们研究了这些 β 亚基在吡喹酮（目前抗血吸虫病的首选药物）的作用中可能发挥的作用。我们还提供了证据表明，在其他吡喹酮敏感的扁形动物（如猪肉绦虫、猪带绦虫）中也发现了 Ca-nu beta var 同源物，因此这些变体 P 亚基可能代表扁形动物特异性基因家族。 (c) 2006 年澳大利亚寄生虫学会公司由 Elsevier Ltd 出版。保留所有权利。
Voltage-gated calcium (Ca2+) channels provide the pathway for Ca2+ influxes that underlie Ca2+-dependent responses in muscles, nerves and other excitable cells. They are also targets of a wide variety of drugs and toxins. Ca2+ channels are multisubunit protein complexes consisting of a pore-forming a, subunit and other modulatory subunits, including the beta subunit. Here, we review the structure and function of schistosome Ca2+ channel subunits, with particular emphasis on variant Ca2+ channel beta subunits (Ca-nu beta var) found in these parasites. In particular, we examine the role these beta subunits may play in the action of praziquantel, the current drug of choice against schistosomiasis. We also present evidence that Ca-nu beta var homologs are found in other praziquantel-sensitive platyhelminths such as the pork tapeworm, Taenia solium, and that these variant P subunits may thus represent a platyhelminth-specific gene family. (c) 2006 Australian Society for Parasitology Inc Published by Elsevier Ltd. All rights reserved.