Hypobetalipoproteinemia is associated with low levels of hemostatic risk factors in the Framingham offspring population.
Hypobetalipoproteinemia is associated with low levels of hemostatic risk factors in the Framingham offspring population.
复制标题
低β脂蛋白血症与弗雷明汉后代群体中低水平的止血危险因素有关。
DOI：
10.1161/01.cir.95.4.825
复制
发表时间：
1997
期刊：
影响因子：
37.8
通讯作者：
Tofler,GH
中科院分区：
文献类型：
--
作者：
Welty,FK;Mittleman,MA;Wilson,PW;Sutherland,PA;Matheney,TH;Lipinska,I;Muller,JE;Levy,D;Tofler,GH
BackgroundGiven the importance of thrombosis in causation of acute coronary syndromes, it is possible that the beneficial effect of low lipid levels on the risk of coronary events is achieved by lowering thrombotic potential of the blood. Hypobetalipoproteinemia is characterized by plasma concentrations of apolipoprotein B and LDL cholesterol that are one third of those observed in the general population. The aim of this study was to utilize subjects with hypobetalipoproteinemia to examine the relation between thrombotic potential and low levels of LDL cholesterol.Methods and ResultsHemostatic risk factors were measured in 1878 individuals (1003 women and 875 men) participating in cycle 5 of the Framingham Offspring Study. The subjects were divided into five groups on the basis of LDL cholesterol level. Subjects with hypobetalipoproteinemia (LDL cholesterol <70 mg/dL) had the lowest levels of fibrinogen, plasminogen activator inhibitor–1 antigen, and tissue plasminogen activator antigen. As LDL cholesterol increased, there was a significant increase in the levels of the hemostatic risk factors, with the exception of von Willebrand factor antigen. Adjustment with multivariate regression analyses for the covariates age, sex, body mass index, diabetes mellitus, smoking, alcohol intake, triglyceride level, and use of antihypertensive medication did not materially alter the results.ConclusionsDecreasing levels of LDL cholesterol are associated with decreasing levels of hemostatic risk factors. Subjects with hypobetalipoproteinemia have the lowest levels of hemostatic risk factors and may be protected against thrombotic complications of atherosclerotic cardiovascular disease because of reduced thrombotic potential. One mechanism by which lipid-lowering therapy may decrease clinical cardiac events is through a reduction in thrombotic tendency.
