The canine cognitive dysfunction rating scale (CCDR): A data-driven and ecologically relevant assessment tool
The canine cognitive dysfunction rating scale (CCDR): A data-driven and ecologically relevant assessment tool
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DOI：
10.1016/j.tvjl.2010.05.014
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发表时间：
2011-06-01
影响因子：
2.2
通讯作者：
Valenzuela, Michael J.
中科院分区：
文献类型：
--
作者：
Salvin, Hannah E.;McGreevy, Paul D.;Valenzuela, Michael J.
犬认知功能障碍（CCD）是一种与年龄相关的神经行为综合征，虽然常见，但在社区犬中诊断严重不足。本研究使用老年犬（n = 957）的大型横断面调查数据，旨在开发一种用于评估CCD的临床量表。数据驱动的分析技术被用来将27个重要的行为项目（以前确定为与CCD相关）纳入一个具有最大认知行为广度的评估工具，同时保持临床实用性。结果CCD评定量表（CCDR）包括13个行为项目，其中3个是敏感的疾病阶段的严重程度，当测试的一个独立的调查样本，CCDR有一个整体的诊断准确率为98.9%，阳性预测值为77.8%，阴性预测值为99.3%。CCDR在2个月内的重测信度也很高（r = 0.73，P <0.0001）。结合兽医评估，CCDR可以成为研究和临床环境中评估和纵向跟踪认知变化的有价值的工具。(C)2010爱思唯尔有限公司版权所有。
Canine cognitive dysfunction (CCD) is an age-related neurobehavioural syndrome which, although common, is severely under-diagnosed in community-based dogs. Using data from a large cross-sectional survey of older dogs (n = 957), this study aimed to develop a clinical scale for assessing CCD. Data-driven analytical techniques were used to distil 27 significant behavioural items (previously identified as relevant to CCD) into an assessment tool with maximal cognito-behavioural breadth whilst maintaining clinical utility. The resulting CCD rating scale (CCDR) comprised 13 behavioural items, of which three were sensitive to the severity of the disease stage.When tested on an independent survey sample, the CCDR had an overall 98.9% diagnostic accuracy with a 77.8% positive predictive value and a 99.3% negative predictive value. Test-re-test reliability of the CCDR over 2 months was also high (r = 0.73, P < 0.0001). In conjunction with veterinary assessment, the CCDR could be a valuable tool in research and clinical settings for both the assessment and longitudinal tracking of cognitive change. (C) 2010 Elsevier Ltd. All rights reserved.