CHANGES IN BRAIN REGIONAL MANGANESE AND MAGNESIUM LEVELS DURING POSTNATAL-DEVELOPMENT - MODULATIONS BY CHRONIC MANGANESE ADMINISTRATION
CHANGES IN BRAIN REGIONAL MANGANESE AND MAGNESIUM LEVELS DURING POSTNATAL-DEVELOPMENT - MODULATIONS BY CHRONIC MANGANESE ADMINISTRATION
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DOI：
10.1007/bf01000438
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发表时间：
1992-03-01
影响因子：
3.6
通讯作者：
LAI, JCK
中科院分区：
文献类型：
--
作者：
CHAN, AWK;MINSKI, MJ;LAI, JCK
本文用中子活化分析法研究了对照组和锰处理组（每毫升饮水含10毫克MnCl_2.4H_2 O）大鼠生后发育过程中下丘脑、小脑、脑桥和髓质、纹状体、中脑和大脑皮质中锰（Mn）和镁（Mg）的含量。年龄依赖性锰积累表现出区域性变化：在第5天，这种积累是最显着的纹状体（12.05 μ g/g湿重），但最不显着的大脑皮层（0.85 μ g/g湿重）。到第10天，脑桥和髓质，下丘脑的区域，分别为最高（4.73 μ g/g湿重）和最低（0.52 μ g/g湿重）锰水平。相比之下，大脑区域锰的变化不太明显，在断奶和成年大鼠。年龄依赖性镁积累显示区域变化在第5天，最显着的脑桥和髓质（720 μ g/g湿重）和最不显着的大脑皮质（295 μ g/g湿重）。所有区域的镁水平在第5天后下降;到第120天，只有大脑皮层的镁水平低于其他区域的水平（后者非常相似）。一般而言，与年龄相关的Mn和Mg水平的降低与含水量的降低和组织重量的增加相一致，这表明血脑屏障的成熟可能在脑Mn和Mg稳态中起重要作用。慢性锰治疗从概念开始改变了区域锰和镁的分布模式在发展过程中。我们的研究结果是一致的假设，慢性锰中毒发挥调节作用的大脑区域代谢和动态平衡的锰和其他金属在发展过程中。
Manganese (Mn) and magnesium (Mg) levels in hypothalamus, cerebellum, pons and medulla, striatum, midbrain, and cerebral cortex of control and Mn-treated (10 mg MnCl2.4H2O per ml of drinking water) rats during postnatal development were studied using instrumental neutron activation analysis. The age-dependent Mn accumulation showed regional variation: at day 5, this accumulation was most marked in striatum (12.05-mu-g/g wet weight) but least marked in cerebral cortex (0.85-mu-g/g wet weight). By day 10, pons and medulla, and hypothalamus were regions with, respectively, the highest (4.73-mu-g/g wet weight) arid the lowest (0.52-mu-g/g wet weight) Mn levels. By contrast, brain regional Mn variations were less pronounced in weanling and adult rats. The age-dependent Mg accumulation showed regional variation at day 5, being most marked in pons arid medulla (720-mu-g/g wet weight) and least marked in cerebral cortex (295 mu-g/g wet weight). Mg levels in all regions decreased after day 5; by day 120, only Mg level in cerebral cortex was lower than levels in other regions (the latter being very similar). In general, the age-related decreases in Mn and Mg levels paralleled the decreases in water content and increases in tissue weight, suggesting that the maturation of the blood-brain barrier may play important role(s) in brain Mn arid Mg homeostasis. Chronic Mn-treatment from conception onwards altered the regional Mn and Mg distribution patterns during development. Our results are consistent with the hypothesis that chronic Mn toxicity exerts modulatory effects on brain regional metabolism and homeostasis of Mn and other metals during development.