Direction- and rate-dependent fractionation during atrial fibrillation persistence: Unmasking cardiac anisotropy?
Direction- and rate-dependent fractionation during atrial fibrillation persistence: Unmasking cardiac anisotropy?
复制标题
DOI：
10.1111/jce.14597
复制
发表时间：
2020-06-11
影响因子：
2.7
通讯作者：
de Groot, Natasja M. S.
中科院分区：
文献类型：
--
作者：
Starreveld, Roeliene;de Groot, Natasja M. S.
这个人类病例是第一个说明高分辨率单极心房电位中方向和频率依赖性各向异性传导的形态学表现。在一名76岁的长期持续性房颤（AF）患者中，过早冲动诱导低振幅、碎裂细胞外电位，持续时间异常延长，表明各向异性传导的方向依赖性。起搏频率增加诱导出现类似的碎裂电位，反映了频率依赖性各向异性和不均匀、缓慢传导。从不同部位以不同速率起搏有助于识别不均匀的各向异性组织，从而识别AF的基底。
This human case is the first to illustrate morphological manifestations of direction- and rate-dependent anisotropic conduction in high-resolution unipolar atrial potentials. Premature impulses induced low-amplitude, fractionated extracellular potentials with exceptionally prolonged durations in a 76-year old longstanding persistent patient with atrial fibrillation (AF), demonstrating direction-dependency of anisotropic conduction. An increased pacing frequency induced presence of similar fractionated potentials, reflecting rate-dependent anisotropy and inhomogeneous, slow conduction. Pacing with different rates and from different sites could aid in identifying nonuniform anisotropic tissue and thus the substrate of AF.