CHOLINESTERASES AND THE PATHOLOGY OF ALZHEIMER-DISEASE
CHOLINESTERASES AND THE PATHOLOGY OF ALZHEIMER-DISEASE
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DOI：
10.1097/00002093-199501002-00005
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发表时间：
1995-01-01
影响因子：
2.1
通讯作者：
MESULAM, MM
中科院分区：
文献类型：
--
作者：
GEULA, C;MESULAM, MM
阿尔茨海默病 (AD) 伴随着与皮质胆碱能轴突和胆碱感受神经元相关的乙酰胆碱酯酶 (AChE) 活性的显着丧失。与此同时，AD 皮质中胆碱酯酶 (ChE) 活性以 AChE 的形式出现，而丁酰胆碱酯酶活性则与斑块、缠结和淀粉样血管病相关。我们的观察表明，与 AD 病理病变相关的 ChE (ADChE) 与与正常神经元和轴突相关的 ChE 相比，具有不同的酶特性，并且很可能具有不同的来源。 ADChE 最有可能具有参与 AD 发病机制的非胆碱能功能。假定的功能包括充当蛋白酶/肽酶，直接参与淀粉样前体蛋白的淀粉样变性加工，并引起神经元过程的异常生长。讨论了 AD ChE 的治疗和诊断意义。
Alzheimer disease (AD) is accompanied by a marked loss of acetylcholinesterase (AChE) activity associated with cortical cholinergic axons and cholinoceptive neurons. Simultaneous with this loss, cholinesterase (ChE) activity emerges in AD cortex in the form of AChE and butyrylcholinesterase activity associated with plaques, tangles, and amyloid angiopathy. Our observations have shown that the ChEs associated with the pathological lesions of AD (ADChEs) possess different enzymatic properties and quite possibly are of a different source as compared with the ChEs associated with normal neurons and axons. The ADChEs most likely have noncholinergic functions involved in the pathogenesis of AD. The postulated functions include acting as proteases/peptidases, participating directly in the amyloidogenic processing of the amyloid precursor protein, and causing aberrant growth of neuronal processes. The therapeutic and diagnostic implications of AD ChEs are discus sed.