PHYSICAL-FITNESS AND ALL-CAUSE MORTALITY - A PROSPECTIVE-STUDY OF HEALTHY-MEN AND WOMEN
PHYSICAL-FITNESS AND ALL-CAUSE MORTALITY - A PROSPECTIVE-STUDY OF HEALTHY-MEN AND WOMEN
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DOI：
10.1001/jama.262.17.2395
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发表时间：
1989-11-03
影响因子：
120.7
通讯作者：
GIBBONS, LW
中科院分区：
文献类型：
--
作者：
BLAIR, SN;KOHL, HW;GIBBONS, LW
我们研究了接受预防性体检的10,224名男性和3,120名女性的身体健康状况和全原因和特定原因死亡的风险。体能通过最大跑台运动试验进行测量。平均随访8年多，共观察110,482人年。男性死亡240人，女性死亡43人。在身体健康五分位数中，年龄调整后的全因死亡率从最不健康男性的64.0/10,000人年下降到最健康男性的18.6/10,000人年(斜率，-4.5)。妇女的相应数值为每10,000人年39.5至每10,000人年8.5(斜率，-5.5)。在对年龄、吸烟习惯、胆固醇水平、收缩压、空腹血糖水平、父母冠心病病史和随访间隔进行统计调整后，这些趋势仍然存在。在高健身类别中，心血管疾病和癌症的死亡率也较低。全因死亡率的归因风险估计表明，身体健康状况不佳是男性和女性的一个重要风险因素。更高水平的身体健康可以延缓主要由于心血管疾病和癌症发病率降低而导致的全因死亡。
We studied physical fitness and risk of all-cause and cause-specific mortality in 10,224 men and 3,120 women who were given a preventive medical examination. Physical fitness was measured by a maximal treadmill exercise test. Average follow-up was slightly more than 8 years, for a total of 110,482 person-years of observation. There were 240 deaths in men and 43 deaths in women. Age-adjusted all-cause mortality rates declined across physical fitness quintiles from 64.0 per 10,000 person-years in the least-fit men to 18.6 per 10,000 person-years in the most-fit men (slope, -4.5). Corresponding values for women were 39.5 per 10,000 person-years to 8.5 per 10,000 person-years (slope, -5.5). These trends remained after statistical adjustment for age, smoking habit, cholesterol level, systolic blood pressure, fasting blood glucose level, parental history of coronary heart disease, and follow-up interval. Lower mortality rates in higher fitness categories also were seen for cardiovascular disease and cancer of combined sites. Attributable risk estimates for all-cause mortality indicated that low physical fitness was an important risk factor in both men and women. Higher levels of physical fitness apepar to delay all-cause mortality primarily due to lowered rates of cardiovascular disease and cancer.