The treatment of advanced stage favorable histology non-Hodgkin's lymphoma: a preliminary report of a randomized trial comparing single agent chemotherapy, combination chemotherapy, and whole body irradiation.
The treatment of advanced stage favorable histology non-Hodgkin's lymphoma: a preliminary report of a randomized trial comparing single agent chemotherapy, combination chemotherapy, and whole body irradiation.
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晚期组织学有利的非霍奇金淋巴瘤的治疗：比较单药化疗、联合化疗和全身放疗的随机试验的初步报告。
DOI：
10.1182/blood.v58.3.592.bloodjournal583592
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发表时间：
1981
期刊：
影响因子：
20.3
通讯作者：
B. W. Brown
中科院分区：
文献类型：
--
作者：
R. Hoppe;P. Kushlan;H. Kaplan;S. Rosenberg;B. W. Brown
1975 年至 1978 年间，51 名组织学良好的非霍奇金淋巴瘤、病理分期 III-IV 期患者接受了随机治疗方案的前瞻性治疗。治疗选择包括单一烷化剂化疗、环磷酰胺、长春新碱和泼尼松 (CVP) 联合化疗，或分次全身照射，然后进行低剂量相关野照射。本组患者的中位随访间隔不是 41 个月。整个组的精算生存率非常好，4 年时为 84%，三种治疗方案的生存率相似。三个治疗组的初始完全缓解率（64%、88% 和 71%）没有显着差异。然而，初次缓解诱导后复发频繁，4 年无复发率仅为 25%。三种疗法的毒性是可以接受的。 CVP 治疗组的急性治疗并发症最多；然而，长期血液抑制最常见于接受全身照射治疗的患者。一般来说，在初始治疗时有骨髓受累和脾脏完整的患者中，血液学并发症更常见。讨论了本研究与治疗晚期组织学淋巴瘤患者的其他临床试验的关系及其对未来临床试验的影响。
Between 1975 and 1978, 51 patients with favorable histology non-Hodgkin's lymphomas, pathologic stage III-IV, were treated prospectively on a randomized treatment protocol. Treatment options were single alkylating agent chemotherapy, combination chemotherapy with cyclophosphamide, vincristine, and prednisone (CVP), or fractionated whole body irradiation followed by low dose involved field irradiation. The median follow-up interval in this group of patients is not 41 mo. Actuarial survival is excellent, 84% at 4 yr for the entire group, with similar survival observed for each of the three treatment options. Initial complete remission rates (64%, 88%, and 71%) were not significantly different in the three treatment arms. Frequent relapse after initial remission induction was noted, however, with a freedom from relapse at 4 yr of only 25%. The toxicities of the three therapies were acceptable. Acute complications of therapy were most numerous in the group of patients treated with CVP; however, long-term hematologic depression was most commonly observed in patients treated with whole body irradiation. In general, hematologic complications were more frequent among patients who had marrow involvement and intact spleens at the time of initial therapy. The relationship of this study to other clinical trials in the management of patients with advanced stage favorable histology lymphomas and its implications for future clinical trials are discussed.
惰性非霍奇金淋巴瘤的治疗。
影响因子：
4
作者：
Portlock,CS
通讯作者：
Portlock,CS