Increased mitochondrial superoxide dismutase activity in Parkinson's disease but not amyotrophic lateral sclerosis motor cortex
Increased mitochondrial superoxide dismutase activity in Parkinson's disease but not amyotrophic lateral sclerosis motor cortex
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帕金森病中线粒体超氧化物歧化酶活性增加，但肌萎缩侧索硬化症运动皮层中线粒体超氧化物歧化酶活性增加
DOI：
10.1016/s0304-3940(97)00905-1
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发表时间：
1997
影响因子：
2.5
通讯作者：
P. Leigh
中科院分区：
文献类型：
--
作者：
A. Radunović;W. G. Pôrto;S. Zeman;P. Leigh
氧化应激可能导致肌萎缩侧索硬化症（ALS）和帕金森病（PD）的神经退行性过程。运动皮质在PD不受影响，其列入自由基参与ALS发病机制的研究可能有助于阐明氧化应激是否是疾病特异性或更广泛的现象存在于神经变性。我们已经测量了细胞溶质和线粒体的超氧化物歧化酶（SOD），抗氧化酶参与初级防御自由基损伤，在运动皮质的6例散发型ALS（SALS），8例PD和8例正常对照组。我们发现，在SALS和对照运动皮层之间的细胞溶质和线粒体SOD的活性没有差异。然而，PD运动皮层的线粒体SOD活性显著高于SALS和对照运动皮层，而胞浆SOD活性低于其他两组，但差异无统计学意义。我们的研究结果表明，PD中存在改变的抗氧化防御系统，但不存在ALS上运动神经元，这表明氧化应激可能是PD中的一种普遍现象。
Oxidative stress may contribute to the neurodegenerative process in amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). Motor cortex in PD is not affected and its inclusion in studies of free radical involvement in ALS pathogenesis could help elucidate whether oxidative stress is disease specific or a more widespread phenomenon present in the neurodegeneration. We have measured cytosolic and mitochondrial isoforms of superoxide dismutase (SOD), antioxidant enzymes involved in primary defence against free radical damage, in motor cortex of six patients with sporadic form of ALS (SALS), eight with PD and eight normal control subjects. We have found no difference in the activities of cytosolic and mitochondrial SOD between SALS and control motor cortex. Mitochondrial SOD activity in PD motor cortex was, however, significantly higher than in SALS and control motor cortex whereas activity of cytosolic SOD was lower than in two other groups although the differences were not statistically significant. Our findings indicate the presence of an altered antioxidant defence system in PD but not ALS upper motor neurons, suggesting that oxidative stress may be a widespread phenomenon in PD.
DOI：
10.1073/pnas.93.10.4565
发表时间：
1996-05-14
影响因子：
11.1
作者：
Przedborski, S;JacksonLewis, V;Dawson, TM
通讯作者：
Dawson, TM