Correlation of microvascular permeability derived from dynamic contrast-enhanced MR imaging with histologic grade and tumor labeling index: A study in human brain tumors
Correlation of microvascular permeability derived from dynamic contrast-enhanced MR imaging with histologic grade and tumor labeling index: A study in human brain tumors
复制标题
DOI：
10.1016/s1076-6332(03)80545-7
复制
发表时间：
2001-05-01
影响因子：
4.8
通讯作者：
Dillon, WP
中科院分区：
文献类型：
--
作者：
Roberts, HC;Roberts, TPL;Dillon, WP
基本原理和目标。动态对比材料增强磁共振（MR）成像可用于量化人脑肿瘤的血容量分数（fBV）和微血管通透性。假设这些测量结果与肿瘤组织学制作和免疫组织学评估的有丝分裂活性相关。材料和方法。 38 名新诊断的神经胶质瘤患者接受了 MR 成像，包括在单剂量钆双胺推注后稳态图像集中的动态三维破坏梯度回忆采集。对血液和组织中的信号强度变化进行动力学分析，得出 fBV 和微血管通透性 (k) 的估计值。肿瘤标本按照世界卫生组织II级四分制评分标准进行分级。对 22 名患者进行 MIB-1 免疫组织化学标记（抗 Ki-67 单克隆抗体）以评估有丝分裂活性。结果。组织学研究显示有 9 个 2 级肿瘤、14 个 3 级肿瘤和 15 个 4 级肿瘤。 fBV 范围为 0.4% 至 24%，k 范围为 -0.4 至 31.4 mL/100 cm(3) (.) min，MIB-1 标记指数范围为 1.7% 至 42.8%。渗透性与肿瘤分级的相关性最高 (r = 0.73)，其次是 MIB-1 指数 (r = 0.63) 和 fBV (v = 0.48)。 k 和 MIB-1 指数之间的相关性很强 (r = 0.84)。任何组的 fBV 之间均无统计学显着差异。尽管不同级别的特定肿瘤的渗透性值之间存在一些重叠，但差异具有统计学意义。 MIB-1指数在3年级和4年级之间有显着差异，但在3年级和3年级之间没有显着差异。结论。动态对比增强 MR 成像可以无创测定肿瘤 fBV 和微血管通透性 ii。对于区分 2 级和 3 级肿瘤，k 比 MIB-1 标记指数更可靠。
Rationale and Objectives. Dynamic contrast material-enhanced magnetic resonance (MR) imaging may be used to quantify fractional blood volume (fBV) and microvascular permeability in human brain tumors. Hypothesis is that these measurements correlate with tumor histologic made and immunohistologically assessed mitotic activity.Materials and Methods. Thirty-eight patients with newly diagnosed gliomas underwent MR imaging consisting of dynamic three-dimensional spoiled gradient-recalled acquisition in the steady state image sets following bolus injections of a single dose of gadodiamide. Signal intensity changes in blood and tissue were kinetically analyzed, yielding estimates of fBV and microvascular permeability (k). Tumor specimens were graded with the World Health Organization-II four-point grading score. MIB-1 immunohistochemical labeling (anti-Ki-67 monoclonal antibody) was performed in 22 patients to evaluate mitotic activity.Results. Histologic study revealed nine grade 2, 14 grade 3, and 15 grade 4 tumors. fBV ranged from 0.4% to 24%, k from -0.4 to 31.4 mL/100 cm(3) (.) min, and MIB-1 labeling indexes from 1.7% to 42.8%. Correlation to the tumor grade was highest for permeability (r = 0.73), followed by the MIB-1 index (r = 0.63), and fBV (v = 0.48). Correlation between k and MIB-1 index was strong (r = 0.84). There was no statistically significant difference between the fBV of any of the groups. Despite some overlap between the permeability values of specific tumors from different grades, differences were statistically significant. The MIB-1 index was significantly different between grades 3 and 4 but not between grades 3 and 3.Conclusion. Dynamic contrast-enhanced MR imaging allows noninvasive determination of tumor fBV and microvascular permeability ii. k is more reliable than the MIB-1 labeling index for differentiating grade 2 from grade 3 tumors.