Ethnic-specific differences in bronchodilator responsiveness among African americans, Puerto ricans, and Mexicans with asthma
Ethnic-specific differences in bronchodilator responsiveness among African americans, Puerto ricans, and Mexicans with asthma
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DOI：
10.1080/02770900701554441
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发表时间：
2007-01-01
影响因子：
1.9
通讯作者：
González, Esteban
中科院分区：
文献类型：
--
作者：
Naqvi, Mariam;Thyne, Shannon;González, Esteban
社会经济和环境差异并不能完全解释波多黎各人、非裔美国人和墨西哥裔美国人之间哮喘患病率、发病率和死亡率的差异。对沙丁胺醇反应的差异可能是一个因素。我们比较了这三个人群之间的支气管扩张剂反应性。所有组均表现出低于预期的反应性。所有年龄段的波多黎各人和患有中度至重度哮喘的非洲裔美国儿童的反应性最低。在中度至重度哮喘受试者中，儿童甚至比成人更不可能表现出预期的支气管扩张剂反应。我们的结论是，支气管扩张剂药物反应性的种族特异性差异存在于墨西哥人，波多黎各人和非洲裔美国人之间的哮喘。这在哮喘管理中可能很重要。
Socioeconomic and environmental differences do not fully explain differences in asthma prevalence, morbidity, and mortality among Puerto Ricans, African Americans, and Mexican Americans. Differences in response to albuterol may be a factor. We compared bronchodilator responsiveness between these three populations. All groups demonstrated below expected responsiveness. Puerto Ricans of all ages and African American children with moderate-to-severe asthma demonstrated the lowest responsiveness overall. Among subjects with moderate-to-severe asthma, children were even less likely than adults to show the expected bronchodilator response. We conclude that ethnic-specific differences in bronchodilator drug responsiveness exist between Mexicans, Puerto Ricans, and African Americans with asthma. This may be of importance in asthma management.