BoLA-DR peptide binding pockets are fundamental for foot-and-mouth disease virus vaccine design in cattle
BoLA-DR peptide binding pockets are fundamental for foot-and-mouth disease virus vaccine design in cattle
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DOI：
10.1016/j.vaccine.2009.09.131
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发表时间：
2009-12-10
期刊：
影响因子：
5.5
通讯作者：
Glass, E. J.
中科院分区：
文献类型：
--
作者：
Baxter, R.;Craigmile, S. C.;Glass, E. J.
本大型研究探讨了牛主要组织相容性复合体DRB3等位基因及其结合囊与对口蹄疫病毒（FMDV）衍生的40-mer肽的免疫应答之间的关系。对杂交牛（Charolais和Holstein）群体（n = 197）进行FMDV肽免疫，并测量了特异性IgG1和IgG2应答，在该群体中检测到18种不同的DRB3等位基因。有几个与抗体应答高度相关的等位基因DRB3*1601与IgG1和IgG2应答相对较低相关
This large study investigates the associations between bovine major histocompatibility complex DRB3 alleles and their binding pockets with the immune response to a 40-mer peptide derived from foot-and-mouth disease virus (FMDV) VPI A crossbred (Charolais and Holstein) cattle population (n = 197) was immumsed with the FMDV peptide and specific IgG1 and IgG2 responses were measured Eighteen different DRB3 alleles were detected in this population. with several exhibiting highly significant associations with antibody response Allele DRB3*1601 was correlated with relatively low IgG1 and IgG2 responses (p