COMPETITIVE-EXCLUSION OF DIARRHEOGENIC ESCHERICHIA-COLI (ETEC) FROM HUMAN ENTEROCYTE-LIKE CACO-2 CELLS BY HEAT-KILLED LACTOBACILLUS
COMPETITIVE-EXCLUSION OF DIARRHEOGENIC ESCHERICHIA-COLI (ETEC) FROM HUMAN ENTEROCYTE-LIKE CACO-2 CELLS BY HEAT-KILLED LACTOBACILLUS
复制标题
DOI：
10.1016/0378-1097(92)90700-x
复制
发表时间：
1992-03-15
影响因子：
2.1
通讯作者：
SERVIN, AL
中科院分区：
文献类型：
--
作者：
CHAUVIERE, G;COCONNIER, MH;SERVIN, AL
携带CFA/I或CFA/II粘附因子的致泻性大肠杆菌（ETEC）特异性地粘附在培养的极化的人肠上皮Caco-2细胞的刷状缘上。粘附在Caco-2细胞上的热灭活的嗜酸乳杆菌菌株LB以浓度依赖性方式抑制产肠杆菌性大肠杆菌粘附。自从L.嗜酸乳杆菌不表达ETEC-CFA粘附因子，因此推测热灭活的嗜酸乳杆菌可能是嗜酸乳杆菌。嗜酸乳杆菌LB细胞抑制大肠杆菌E.通过人肠细胞ETEC受体的空间位阻作用使大肠杆菌附着。
Diarrheagenic Escherichia coli (ETEC) bearing CFA/I or CFA/II adhesive factors specifically adhere onto the brush border of the polarized epithelial human intestinal Caco-2 cells in culture. Heat-killed Lactobacillus acidophilus strain LB, that adheres onto Caco-2 cells, inhibits diarrheagenic Escherichia coli adhesion in a concentration-dependent manner. Since the L. acidophilus does not express ETEC-CFA adhesive factors, it can be postulated that the heat-killed L. acidophilus LB cells inhibit diarrheagenic E. coli attachment by steric hindrance of the human enterocytic ETEC receptors.