EHDs meet the retromer: Complex regulation of retrograde transport.
EHDs meet the retromer: Complex regulation of retrograde transport.
复制标题
EHD符合缩回剂：逆行运输的复杂调节。
DOI：
10.4161/cl.20582
复制
发表时间：
2012-07-01
期刊：
影响因子：
--
通讯作者：
Caplan S
中科院分区：
文献类型：
--
作者：
Zhang J;Naslavsky N;Caplan S
逆行运输介导内吞膜从内体到反式高尔基网络（TGN）的运输。这些通路的失调会导致多种疾病，包括晚发性阿尔茨海默病。逆转录复合体是逆行转运的关键调控因子之一，它受到许多因素的严格控制，包括c端Eps15同源结构域（EHD）蛋白。这篇综述主要关注最近的发现，并讨论了EHD1蛋白和新的EHD1相互作用伙伴Rabankyrin-5 （Rank-5）对逆转录复合物的调控。
Retrograde trafficking mediates the transport of endocytic membranes from endosomes to the trans-Golgi network (TGN). Dysregulation of these pathways can result in multiple ailments, including late-onset Alzheimer disease. One of the key retrograde transport regulators, the retromer complex, is tightly controlled by many factors, including the C-terminal Eps15 homology domain (EHD) proteins. This mini-review focuses on recent findings and discusses the regulation of the retromer complex by EHD proteins and the novel EHD1 interaction partner, Rabankyrin-5 (Rank-5).